Constriction of the mitochondrial inner compartment is a priming event for mitochondrial division
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cho, Bongki | - |
dc.contributor.author | Cho, Hyo Min | - |
dc.contributor.author | Jo, Youhwa | - |
dc.contributor.author | Kim, Hee Dae | - |
dc.contributor.author | Song, Myungjae | - |
dc.contributor.author | Moon, Cheil | - |
dc.contributor.author | Kim, Hyongbum | - |
dc.contributor.author | Kim, Kyungjin | - |
dc.contributor.author | Sesaki, Hiromi | - |
dc.contributor.author | Rhyu, Im Joo | - |
dc.contributor.author | Kim, Hyun | - |
dc.contributor.author | Sun, Woong | - |
dc.date.accessioned | 2021-09-03T05:07:06Z | - |
dc.date.available | 2021-09-03T05:07:06Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-06-09 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/83147 | - |
dc.description.abstract | Mitochondrial division is critical for the maintenance and regulation of mitochondrial function, quality and distribution. This process is controlled by cytosolic actin-based constriction machinery and dynamin-related protein 1 (Drp1) on mitochondrial outer membrane (OMM). Although mitochondrial physiology, including oxidative phosphorylation, is also important for efficient mitochondrial division, morphological alterations of the mitochondrial inner-membrane (IMM) have not been clearly elucidated. Here we report spontaneous and repetitive constriction of mitochondrial inner compartment (CoMIC) associated with subsequent division in neurons. Although CoMIC is potentiated by inhibition of Drp1 and occurs at the potential division spots contacting the endoplasmic reticulum, it appears on IMM independently of OMM. Intra-mitochondrial influx of Ca2+ induces and potentiates CoMIC, and leads to K+-mediated mitochondrial bulging and depolarization. Synergistically, optic atrophy 1 (Opa1) also regulates CoMIC via controlling Mic60-mediated OMM-IMM tethering. Therefore, we propose that CoMIC is a priming event for efficient mitochondrial division. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | OXIDATIVE-PHOSPHORYLATION | - |
dc.subject | FISSION | - |
dc.subject | DYNAMIN | - |
dc.subject | MEMBRANE | - |
dc.subject | OPA1 | - |
dc.subject | PROTEIN | - |
dc.subject | DRP1 | - |
dc.subject | RECRUITMENT | - |
dc.subject | RETICULUM | - |
dc.subject | FUSION | - |
dc.title | Constriction of the mitochondrial inner compartment is a priming event for mitochondrial division | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Rhyu, Im Joo | - |
dc.contributor.affiliatedAuthor | Kim, Hyun | - |
dc.contributor.affiliatedAuthor | Sun, Woong | - |
dc.identifier.doi | 10.1038/ncomms15754 | - |
dc.identifier.scopusid | 2-s2.0-85039844400 | - |
dc.identifier.wosid | 000402964400001 | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, v.8 | - |
dc.relation.isPartOf | NATURE COMMUNICATIONS | - |
dc.citation.title | NATURE COMMUNICATIONS | - |
dc.citation.volume | 8 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | OXIDATIVE-PHOSPHORYLATION | - |
dc.subject.keywordPlus | FISSION | - |
dc.subject.keywordPlus | DYNAMIN | - |
dc.subject.keywordPlus | MEMBRANE | - |
dc.subject.keywordPlus | OPA1 | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | DRP1 | - |
dc.subject.keywordPlus | RECRUITMENT | - |
dc.subject.keywordPlus | RETICULUM | - |
dc.subject.keywordPlus | FUSION | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.