Overcoming the Limits of Hypoxia in Photodynamic Therapy: A Carbonic Anhydrase IX-Targeted Approach
DC Field | Value | Language |
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dc.contributor.author | Jung, Hyo Sung | - |
dc.contributor.author | Han, Jiyou | - |
dc.contributor.author | Shi, Hu | - |
dc.contributor.author | Koo, Seyoung | - |
dc.contributor.author | Singh, Hardev | - |
dc.contributor.author | Kim, Hyo-Jin | - |
dc.contributor.author | Sessler, Jonathan L. | - |
dc.contributor.author | Lee, Jin Yong | - |
dc.contributor.author | Kim, Jong-Hoon | - |
dc.contributor.author | Kim, Jong Seung | - |
dc.date.accessioned | 2021-09-03T05:07:49Z | - |
dc.date.available | 2021-09-03T05:07:49Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-06-07 | - |
dc.identifier.issn | 0002-7863 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/83151 | - |
dc.description.abstract | A major challenge in photodynamic cancer therapy (PDT) is avoiding PDT-induced hypoxia, which can lead to cancer recurrence and progression through activation of various angiogenic factors and significantly reduce treatment outcomes. Reported here is an acetazolamide (AZ)-conjugated BODIPY photosensitizer (AZ-BPS) designed to mitigate the effects of PDT-based hypoxia by combining the benefits of anti-angiogenesis therapy with PDT. AZ-BPS showed specific affinity to aggressive cancer cells (MDA-MB-231 cells) that overexpress carbonic anhydrase IX (CAIX). It displayed enhanced photocytotoxicity compared to a reference compound, BPS, which is an analogous PDT agent that lacks an acetazolamide unit. AZ-BPS also displayed an enhanced in vivo efficacy in a xenograft mouse tumor regrowth model relative to BPS, an effect attributed to inhibition of tumor angiogenesis by both PDT-induced ROS generation and CAIX knockdown. AZ-BPS was evaluated successfully in clinical samples collected from breast cancer patients. We thus believe that the combined approach described here represents an attractive therapeutic approach to targeting CAIX-overexpressing tumors. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | GROWTH-FACTOR EXPRESSION | - |
dc.subject | TUMOR-GROWTH | - |
dc.subject | ANGIOGENESIS | - |
dc.subject | CANCER | - |
dc.subject | METASTASIS | - |
dc.subject | INHIBITORS | - |
dc.subject | CELLS | - |
dc.subject | ACID | - |
dc.subject | VEGF | - |
dc.title | Overcoming the Limits of Hypoxia in Photodynamic Therapy: A Carbonic Anhydrase IX-Targeted Approach | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jong-Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Jong Seung | - |
dc.identifier.doi | 10.1021/jacs.7b02396 | - |
dc.identifier.scopusid | 2-s2.0-85020382009 | - |
dc.identifier.wosid | 000403136500023 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.139, no.22, pp.7595 - 7602 | - |
dc.relation.isPartOf | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | - |
dc.citation.title | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | - |
dc.citation.volume | 139 | - |
dc.citation.number | 22 | - |
dc.citation.startPage | 7595 | - |
dc.citation.endPage | 7602 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | GROWTH-FACTOR EXPRESSION | - |
dc.subject.keywordPlus | TUMOR-GROWTH | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | METASTASIS | - |
dc.subject.keywordPlus | INHIBITORS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordPlus | VEGF | - |
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