Fabrication of electrospun antioxidant nanofibers by rutin-pluronic solid dispersions for enhanced solubility
- Authors
- Lee, Il Woo; Li, Jinglei; Chen, Xiguang; Park, Hyun Jin
- Issue Date
- 6월-2017
- Publisher
- WILEY
- Keywords
- drug delivery systems; electrospinning; hydrophilic polymers; polysaccharides
- Citation
- JOURNAL OF APPLIED POLYMER SCIENCE, v.134, no.21
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF APPLIED POLYMER SCIENCE
- Volume
- 134
- Number
- 21
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/83305
- DOI
- 10.1002/app.44859
- ISSN
- 0021-8995
- Abstract
- In this study, solid dispersions (SDs) and electrospinning combined methods were used to increase the bioavailability and solubility of a water insoluble drug. Pullulan (PUL) nanofibers containing rutin-Pluronic SDs (PUL&RU@ PF) were fabricated by electrospinning. Rutin was efficiently loaded with Pluronic SDs using a facile mixing method and the prepared SDs indicated that 4% w/v Pluronic concentration provided the optimal drug loading efficiency. Scanning electron microscopy (SEM) verified that the morphology of the complex nanofibers had a uniformly smooth surface with a porous structure. The amorphous state of rutin was examined by XRD and DSC. Moreover, rutin in the electrospun PUL-rutin-Pluronic complex structure displayed a fast release profile and equivalent antioxidant ability compared to that of raw rutin. In conclusion, PUL&RU@ PF may be a promising alternative for enhanced solubility and UV stability with remaining rutin's inherent antioxidant ability. (C) 2017 Wiley Periodicals, Inc.
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Collections - Graduate School > Department of Biotechnology > 1. Journal Articles
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