Transferrin saturation concentrations associated with telomeric ageing: a population-based study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shin, Chol | - |
dc.contributor.author | Baik, Inkyung | - |
dc.date.accessioned | 2021-09-03T05:38:43Z | - |
dc.date.available | 2021-09-03T05:38:43Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-06 | - |
dc.identifier.issn | 0007-1145 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/83306 | - |
dc.description.abstract | There are limited data on the association between Fe overload and leucocyte telomere length (LTL), known as a useful biomarker of the replicative ageing of cells. The aim of the study was to evaluate associations between Fe-status biomarkers and LTL. A cross-sectional study included 1174 men and women aged 50-79 years who provided blood samples for assays of Fe-status biomarkers including ferritin, transferrin saturation (TSAT), total Fe-binding capacity (TIBC) and relative LTL. They were free of hepatitis, potential infection or Fe deficiency. In multiple linear regression analysis adjusted for potential confounding variables, log-transformed LTL was positively associated with TIBC (adjusted coefficient estimate for its highest quartile: 0.17 (SE 0.03), P < 0.001) and inversely associated with TSAT (adjusted coefficient estimate for its third and fourth quartiles: -0.09 (SE 0.03), P < 0.01). These associations were consistent after additional adjustment for serum concentrations of high-sensitivity C-reactive protein, alanine transaminase and aspartate transaminase. In particular, participants with not only abnormally high concentrations (>45 %) but also with high-normal concentrations (35-45 %) of TSAT had shorter LTL compared with those with low-normal concentrations (<30 %) (P<0.05). We also observed that less-active or obese persons with high TSAT concentrations had shorter LTL than others. Our findings that cellular ageing is influenced not only by Fe overload but also by high-normal concentrations of TSAT support the hypothesis regarding the detrimental effects of labile Fe, which has a potent pro-oxidant activity in the body. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | CAMBRIDGE UNIV PRESS | - |
dc.subject | IRON-BINDING-CAPACITY | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | MYOCARDIAL-INFARCTION | - |
dc.subject | ALCOHOL-CONSUMPTION | - |
dc.subject | LIPID-PEROXIDATION | - |
dc.subject | GENERAL-POPULATION | - |
dc.subject | RISK-FACTOR | - |
dc.subject | LENGTH | - |
dc.subject | MORTALITY | - |
dc.subject | WOMEN | - |
dc.title | Transferrin saturation concentrations associated with telomeric ageing: a population-based study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shin, Chol | - |
dc.identifier.doi | 10.1017/S0007114517001696 | - |
dc.identifier.scopusid | 2-s2.0-85024499866 | - |
dc.identifier.wosid | 000407571900007 | - |
dc.identifier.bibliographicCitation | BRITISH JOURNAL OF NUTRITION, v.117, no.12, pp.1693 - 1701 | - |
dc.relation.isPartOf | BRITISH JOURNAL OF NUTRITION | - |
dc.citation.title | BRITISH JOURNAL OF NUTRITION | - |
dc.citation.volume | 117 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1693 | - |
dc.citation.endPage | 1701 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | IRON-BINDING-CAPACITY | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | MYOCARDIAL-INFARCTION | - |
dc.subject.keywordPlus | ALCOHOL-CONSUMPTION | - |
dc.subject.keywordPlus | LIPID-PEROXIDATION | - |
dc.subject.keywordPlus | GENERAL-POPULATION | - |
dc.subject.keywordPlus | RISK-FACTOR | - |
dc.subject.keywordPlus | LENGTH | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | WOMEN | - |
dc.subject.keywordAuthor | Iron status | - |
dc.subject.keywordAuthor | Transferrin saturation | - |
dc.subject.keywordAuthor | Telomere length | - |
dc.subject.keywordAuthor | Iron overload | - |
dc.subject.keywordAuthor | General populations | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.