Prognostic significance of focal lesions and diffuse infiltration on MRI for multiple myeloma: a meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Lee, So-Yeon | - |
dc.contributor.author | Kim, Hyun-Jung | - |
dc.contributor.author | Shin, Yu Ri | - |
dc.contributor.author | Park, Hee-Jin | - |
dc.contributor.author | Lee, Yun-Gyoo | - |
dc.contributor.author | Oh, Suk Joong | - |
dc.date.accessioned | 2021-09-03T05:41:16Z | - |
dc.date.available | 2021-09-03T05:41:16Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-06 | - |
dc.identifier.issn | 0938-7994 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/83328 | - |
dc.description.abstract | MRI of bone marrow of the axial skeleton is recommended for evaluation of multiple myeloma. The impact of bone marrow involvement pattern on MRI for determining progression-free survival (PFS) and overall survival (OS) is not yet clear. We performed a meta-analysis of research on the prognostic significance of MRI patterns for OS and PFS using a random effects model. Databases searched without language restriction were MEDLINE, EMBASE, and the Cochrane Library (January 1976 to April 2014). Manual searches were also conducted. Of 10,953 citations identified in the original search, 10 cohort studies for a total of 2015 patients met the inclusion criteria. Nine of the 10 included studies are from three research groups. Pooled hazard ratios were 1.80 (95 % confidence interval [CI] 1.32-2.46; P < 0.001) for OS and 2.30 (95 % CI 1.65-3.20; P < 0.001) for PFS for focal lesions on MRI; and 1.70 (95 % CI 1.30-2.21; P < 0.001) for OS and 1.74 (95 % CI 1.07-2.85; P = 0.03) for PFS for diffuse infiltration on MRI. No significant heterogeneity was observed among studies. This meta-analysis demonstrated an association between focal lesions and diffuse infiltration and poor prognosis in this population. aEuro cent MRI findings of multiple myeloma include normal, focal, variegated and diffuse infiltration aEuro cent Focal lesions and diffuse infiltration on MRI were poor prognostic factors aEuro cent Bone marrow involvement pattern on MRI can help physicians assess prognosis. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | STEM-CELL TRANSPLANTATION | - |
dc.subject | BONE-MARROW INVOLVEMENT | - |
dc.subject | UNDETERMINED SIGNIFICANCE | - |
dc.subject | MONOCLONAL GAMMOPATHY | - |
dc.subject | CONSENSUS STATEMENT | - |
dc.subject | IMAGING TECHNIQUES | - |
dc.subject | SURVIVAL | - |
dc.subject | PATTERN | - |
dc.subject | PROGRESSION | - |
dc.subject | DIAGNOSIS | - |
dc.title | Prognostic significance of focal lesions and diffuse infiltration on MRI for multiple myeloma: a meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Hyun-Jung | - |
dc.identifier.doi | 10.1007/s00330-016-4543-8 | - |
dc.identifier.scopusid | 2-s2.0-85018285121 | - |
dc.identifier.wosid | 000400359100015 | - |
dc.identifier.bibliographicCitation | EUROPEAN RADIOLOGY, v.27, no.6, pp.2333 - 2347 | - |
dc.relation.isPartOf | EUROPEAN RADIOLOGY | - |
dc.citation.title | EUROPEAN RADIOLOGY | - |
dc.citation.volume | 27 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 2333 | - |
dc.citation.endPage | 2347 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.subject.keywordPlus | STEM-CELL TRANSPLANTATION | - |
dc.subject.keywordPlus | BONE-MARROW INVOLVEMENT | - |
dc.subject.keywordPlus | UNDETERMINED SIGNIFICANCE | - |
dc.subject.keywordPlus | MONOCLONAL GAMMOPATHY | - |
dc.subject.keywordPlus | CONSENSUS STATEMENT | - |
dc.subject.keywordPlus | IMAGING TECHNIQUES | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | PATTERN | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordAuthor | Multiple myeloma | - |
dc.subject.keywordAuthor | MRI | - |
dc.subject.keywordAuthor | Prognosis | - |
dc.subject.keywordAuthor | Bone marrow | - |
dc.subject.keywordAuthor | Meta-analysis | - |
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