A laboratory association between hemoglobin and VerifyNow P2Y12 reaction unit: A systematic review and meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Kim, Yun Gi | - |
dc.contributor.author | Suh, Jung-Won | - |
dc.contributor.author | Sibbing, Dirk | - |
dc.contributor.author | Kastrati, Adnan | - |
dc.contributor.author | Ko, Young-Guk | - |
dc.contributor.author | Jang, Yangsoo | - |
dc.contributor.author | Cho, Young-Seok | - |
dc.contributor.author | Youn, Tae-Jin | - |
dc.contributor.author | Chae, In-Ho | - |
dc.contributor.author | Choi, Dong-Ju | - |
dc.contributor.author | Kim, Hyo-Soo | - |
dc.date.accessioned | 2021-09-03T05:43:08Z | - |
dc.date.available | 2021-09-03T05:43:08Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-06 | - |
dc.identifier.issn | 0002-8703 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/83341 | - |
dc.description.abstract | Background VerifyNow P2Y12 assay is used widely to evaluate residual platelet reactivity in patients taking P2Y12 receptor antagonists. However, a laboratory association between VerifyNow P2Y12 reaction unit (PRU) and hemoglobin, which might lead to wrong interpretation of the data, is reported. We performed these systematic review and meta-analysis to clearly define the relationship between PRU and hemoglobin and to elucidate whether the relationship, if any, is a true biological association or is just a laboratory error. Methods Through a comprehensive electronic and manual search, 10 studies were selected for the cohort level meta analysis. Among 10 studies, we were able to retrieve the raw data of 5 studies, and a patient-level meta-analysis was performed. Potential publication bias was searched by funnel plot analysis and was actively adjusted, if present, by trim and fill method. Results The pooled analysis revealed a significant inverse correlation between PRU and hemoglobin (r = 0.349; P <.001; 10 studies with 4,793 patients). VerifyNow P2Y12 base unit, which reflects off-drug platelet reactivity, was also inversely correlated with hemoglobin (r = 0.526; P<.001; 8 studies with 4,395 patients). % Inhibition (r = 0.081; P =.059; 6 studies with 3,832 patients) and Delta PRU (r = 0.037; P =.188; 5 studies with 3,521 patients) were not associated with hemoglobin. A significant inverse association between PRU and hemoglobin was also observed in the patient-level meta analysis (3,533 patients pooled from 5 studies; r = 0.335; P<.001). Light transmission aggregometry (r = 0.160; P=.072; 4 studies with 1,144 patients) and multiple electrode platelet aggregometry (r = 0.029; P = .394; 3 studies with 7,645 patients) showed no significant association with hemoglobin. Conclusions A significant inverse association was observed between PRU and hemoglobin which is likely to be a laboratory error. Clinicians should be aware that this association might lead to wrong interpretation of the data. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MOSBY-ELSEVIER | - |
dc.subject | PERCUTANEOUS CORONARY INTERVENTION | - |
dc.subject | ELECTRODE PLATELET AGGREGOMETRY | - |
dc.subject | ELUTING STENT IMPLANTATION | - |
dc.subject | ANTIPLATELET THERAPY | - |
dc.subject | ARTERY-DISEASE | - |
dc.subject | CLOPIDOGREL RESPONSIVENESS | - |
dc.subject | MYOCARDIAL-INFARCTION | - |
dc.subject | PUBLICATION BIAS | - |
dc.subject | FUNCTION TESTS | - |
dc.subject | ASSAY | - |
dc.title | A laboratory association between hemoglobin and VerifyNow P2Y12 reaction unit: A systematic review and meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Yun Gi | - |
dc.identifier.doi | 10.1016/j.ahj.2017.03.006 | - |
dc.identifier.scopusid | 2-s2.0-85016066754 | - |
dc.identifier.wosid | 000403197800007 | - |
dc.identifier.bibliographicCitation | AMERICAN HEART JOURNAL, v.188, pp.53 - 64 | - |
dc.relation.isPartOf | AMERICAN HEART JOURNAL | - |
dc.citation.title | AMERICAN HEART JOURNAL | - |
dc.citation.volume | 188 | - |
dc.citation.startPage | 53 | - |
dc.citation.endPage | 64 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.subject.keywordPlus | PERCUTANEOUS CORONARY INTERVENTION | - |
dc.subject.keywordPlus | ELECTRODE PLATELET AGGREGOMETRY | - |
dc.subject.keywordPlus | ELUTING STENT IMPLANTATION | - |
dc.subject.keywordPlus | ANTIPLATELET THERAPY | - |
dc.subject.keywordPlus | ARTERY-DISEASE | - |
dc.subject.keywordPlus | CLOPIDOGREL RESPONSIVENESS | - |
dc.subject.keywordPlus | MYOCARDIAL-INFARCTION | - |
dc.subject.keywordPlus | PUBLICATION BIAS | - |
dc.subject.keywordPlus | FUNCTION TESTS | - |
dc.subject.keywordPlus | ASSAY | - |
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