Neoagarohexaose-mediated activation of dendritic cells via Toll-like receptor 4 leads to stimulation of natural killer cells and enhancement of antitumor immunity
DC Field | Value | Language |
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dc.contributor.author | Lee, Moon Hee | - |
dc.contributor.author | Jang, Jong-Hwa | - |
dc.contributor.author | Yoon, Gun Young | - |
dc.contributor.author | Lee, Seung Jun | - |
dc.contributor.author | Lee, Min-Goo | - |
dc.contributor.author | Kang, Tae Heung | - |
dc.contributor.author | Han, Hee Dong | - |
dc.contributor.author | Kim, Hyuk Soon | - |
dc.contributor.author | Choi, Wahn Soo | - |
dc.contributor.author | Park, Won Sun | - |
dc.contributor.author | Park, Yeong-Min | - |
dc.contributor.author | Jung, In Duk | - |
dc.date.accessioned | 2021-09-03T05:58:05Z | - |
dc.date.available | 2021-09-03T05:58:05Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-05-31 | - |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/83414 | - |
dc.description.abstract | beta-Agarase cleaves the beta-1,4 linkages of agar to produce neoagarooligosaccharides (NAO), which are associated with various physiological functions. However, the immunological functions of NAO are still unclear. In this study, we demonstrated that beta-agarase DagA-produced neoagarohexaose (DP6), an NAO product, promoted the maturation of dendritic cells (DCs) by Toll-like receptor 4 (TLR4). DP6 directly and indirectly enhanced the activation of natural killer (NK) cells in a TLR4-dependent manner in vitro and in vivo. Finally, the antitumor activity of DP6 against B16F1 melanoma cells was inhibited in NK cell-depletion systems by using NK-cell depleting antibodies in vivo. Collectively, the results indicated that DP6 augments antitumor immunity against B16F1 melanoma cells via the activation of DC-mediated NK cells in a TLR4-dependent manner. Thus, DP6 is a potential candidate adjuvant that acts as an immune cell modulator for the treatment of melanoma. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY | - |
dc.subject | CD8(+) T-CELLS | - |
dc.subject | TUMOR | - |
dc.subject | VACCINATION | - |
dc.subject | NK | - |
dc.title | Neoagarohexaose-mediated activation of dendritic cells via Toll-like receptor 4 leads to stimulation of natural killer cells and enhancement of antitumor immunity | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Min-Goo | - |
dc.identifier.doi | 10.5483/BMBRep.2017.50.5.014 | - |
dc.identifier.scopusid | 2-s2.0-85020030223 | - |
dc.identifier.wosid | 000402829600006 | - |
dc.identifier.bibliographicCitation | BMB REPORTS, v.50, no.5, pp.263 - 268 | - |
dc.relation.isPartOf | BMB REPORTS | - |
dc.citation.title | BMB REPORTS | - |
dc.citation.volume | 50 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 263 | - |
dc.citation.endPage | 268 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002225851 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | CD8(+) T-CELLS | - |
dc.subject.keywordPlus | TUMOR | - |
dc.subject.keywordPlus | VACCINATION | - |
dc.subject.keywordPlus | NK | - |
dc.subject.keywordAuthor | Antitumor immunity | - |
dc.subject.keywordAuthor | Dendritic cells | - |
dc.subject.keywordAuthor | Natural killer cells | - |
dc.subject.keywordAuthor | Neoagarohexaose | - |
dc.subject.keywordAuthor | Toll-like receptor 4 | - |
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