The association between genetic polymorphisms of the interleukin-23 receptor gene and susceptibility to uveitis: a meta-analysis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jung, Jae Hyun | - |
dc.contributor.author | Song, Gwan Gyu | - |
dc.contributor.author | Kim, Jae-Hoon | - |
dc.contributor.author | Seo, Young Ho | - |
dc.contributor.author | Choi, Sung Jae | - |
dc.date.accessioned | 2021-09-03T05:58:24Z | - |
dc.date.available | 2021-09-03T05:58:24Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-05-30 | - |
dc.identifier.issn | 1471-2415 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/83416 | - |
dc.description.abstract | Background: Uveitis is an eye inflammatory disease, which is sometimes associated with underlying systemic disease. Interleukin-23 plays an important role in autoimmune disease. The aim of this meta-analysis was to evaluate the association between the interleukin-23 receptor (IL-23R) and susceptibility to uveitis. Methods: Published literature from PUBMED and EMBASE were retrieved. Seven studies were included in this meta-analysis, covering a total of 1309 cases of uveitis and 2400 controls. Meta-analyses were conducted on the associations between uveitisand rs7517847, rs17375018, and rs11209032 polymorphisms in the IL-23R gene. Results: There were no significant associations between IL-23R polymorphisms and uveitis with regard to the following alleles: for G allele vs. T allele of rs7517847, OR 1.01, 95% CI 0.92-1.12, P = 0.83; for A allele vs. G allele of rs17375018, OR 0.68, 95% CI 0.47-0.99, P = 0.05; rs11209032 OR 1.12, 95% CI 0.84-1.51, P = 0.43. In contrast, there were significant associations between the AA + AG gene versus GG gene of rs17375018 and the AA gene versus AG + GG gene of rs11209032 polymorphism with uveitis (OR 0.59, 95% CI 0.35-0.99, P = 0.04; OR 1.32, 95% CI 1.10-1.59, P = 0.003). Conclusions: This meta-analysis suggests that each allele of IL-23R, including rs7519847, rs17375018 and rs11209032 was negatively associated with uveitis. However, homozygote models, including the rs17375018 GG genotype and rs11209032 AA genotype, were significantly associated with uveitis. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | BIOMED CENTRAL LTD | - |
dc.subject | CHINESE HAN POPULATION | - |
dc.subject | BEHCETS-DISEASE | - |
dc.subject | IL-23 | - |
dc.subject | IL-17 | - |
dc.title | The association between genetic polymorphisms of the interleukin-23 receptor gene and susceptibility to uveitis: a meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jung, Jae Hyun | - |
dc.contributor.affiliatedAuthor | Song, Gwan Gyu | - |
dc.contributor.affiliatedAuthor | Choi, Sung Jae | - |
dc.identifier.doi | 10.1186/s12886-017-0477-4 | - |
dc.identifier.scopusid | 2-s2.0-85020046390 | - |
dc.identifier.wosid | 000402961000001 | - |
dc.identifier.bibliographicCitation | BMC OPHTHALMOLOGY, v.17 | - |
dc.relation.isPartOf | BMC OPHTHALMOLOGY | - |
dc.citation.title | BMC OPHTHALMOLOGY | - |
dc.citation.volume | 17 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Ophthalmology | - |
dc.relation.journalWebOfScienceCategory | Ophthalmology | - |
dc.subject.keywordPlus | CHINESE HAN POPULATION | - |
dc.subject.keywordPlus | BEHCETS-DISEASE | - |
dc.subject.keywordPlus | IL-23 | - |
dc.subject.keywordPlus | IL-17 | - |
dc.subject.keywordAuthor | Interleukin-23R | - |
dc.subject.keywordAuthor | Polymorphism | - |
dc.subject.keywordAuthor | Uveitis | - |
dc.subject.keywordAuthor | Meta-analysis | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.