Combination of Helicobacter pylori infection and the interleukin 8-251 T > A polymorphism, but not the mannose-binding lectin 2 codon 54 G > A polymorphism, might be a risk factor of gastric cancer
DC Field | Value | Language |
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dc.contributor.author | Chang, Young Woon | - |
dc.contributor.author | Oh, Chi Hyuk | - |
dc.contributor.author | Kim, Jung-Wook | - |
dc.contributor.author | Lee, Jae Won | - |
dc.contributor.author | Park, Mi Ju | - |
dc.contributor.author | Shim, Jae-Jun | - |
dc.contributor.author | Lee, Chang Kyun | - |
dc.contributor.author | Jang, Jae-Young | - |
dc.contributor.author | Dong, Seok Ho | - |
dc.contributor.author | Kim, Hyo Jong | - |
dc.contributor.author | Kim, Sung Soo | - |
dc.contributor.author | Kim, Byung-Ho | - |
dc.date.accessioned | 2021-09-03T05:58:46Z | - |
dc.date.available | 2021-09-03T05:58:46Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-05-30 | - |
dc.identifier.issn | 1471-2407 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/83418 | - |
dc.description.abstract | Background: Mannose-binding lectin (MBL) acts in the innate immune response to Helicobacter pylori. Interleukin 8 (IL-8) is a potent cytokine produced by gastric epithelial cells in response to H. pylori. We aimed to investigate whether polymorphisms in MBL2 and IL-8 influence susceptibility to H. pylori infection, and the associations of these polymorphisms with the risk of gastroduodenal diseases in a Korean population. Methods: We consecutively enrolled 176 H. pylori-negative control subjects, 221 subjects with H. pylori-positive non-atrophic gastritis, 52 mild atrophic gastritis (AG), 61 severe AG, 175 duodenal ulcer, and 283 gastric cancer (GC). Allele-specific PCR-RFLP was conducted for polymorphisms in MBL2 exon 1 (codon 52, 54, and 57) and IL-8 -251 T > A. IL-8 levels in gastric mucosal tissues and serum MBL levels were measured by enzyme-linked immunosorbent assay. Results: MBL2 exon 1 polymorphic variants were found only in codon 54, and the allele frequencies did not differ significantly between the control and disease groups. Although serum MBL levels in codon 54 A/A mutants were markedly low, it did not influence susceptibility to H. pylori infection or the risk of gastroduodenal diseases. IL-8 levels were significantly different between T/T wild type, T/A heterozygote, and A/A mutant genotypes. IL-8 -251 A allele carriers (A/A + T/A) showed increased IL-8 levels, and were significantly associated with the risk of severe AG and GC. Conclusions: We suggest that a combination of H. pylori infection and the IL-8 -251 T > A polymorphism might increase the risk of severe AG and GC in a Korean population. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | BMC | - |
dc.subject | NECROSIS-FACTOR-ALPHA | - |
dc.subject | GENETIC POLYMORPHISMS | - |
dc.subject | PROTEIN LEVELS | - |
dc.subject | CAGA GENE | - |
dc.subject | CARCINOMA | - |
dc.subject | ALLELE | - |
dc.subject | SUSCEPTIBILITY | - |
dc.subject | INFLAMMATION | - |
dc.subject | PROMOTER | - |
dc.subject | IL-8 | - |
dc.title | Combination of Helicobacter pylori infection and the interleukin 8-251 T > A polymorphism, but not the mannose-binding lectin 2 codon 54 G > A polymorphism, might be a risk factor of gastric cancer | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Jae Won | - |
dc.identifier.doi | 10.1186/s12885-017-3378-2 | - |
dc.identifier.scopusid | 2-s2.0-85019684751 | - |
dc.identifier.wosid | 000402335200005 | - |
dc.identifier.bibliographicCitation | BMC CANCER, v.17 | - |
dc.relation.isPartOf | BMC CANCER | - |
dc.citation.title | BMC CANCER | - |
dc.citation.volume | 17 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | NECROSIS-FACTOR-ALPHA | - |
dc.subject.keywordPlus | GENETIC POLYMORPHISMS | - |
dc.subject.keywordPlus | PROTEIN LEVELS | - |
dc.subject.keywordPlus | CAGA GENE | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | ALLELE | - |
dc.subject.keywordPlus | SUSCEPTIBILITY | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | PROMOTER | - |
dc.subject.keywordPlus | IL-8 | - |
dc.subject.keywordAuthor | Mannose-binding lectin 2 | - |
dc.subject.keywordAuthor | Interleukin 8 | - |
dc.subject.keywordAuthor | Helicobacter pylori | - |
dc.subject.keywordAuthor | Gastric cancer | - |
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