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Neuroprotective constituents from the fruits of Maclura tricuspidata

Authors
Nguyen Tuan HiepKwon, JaeyoungKim, Dong-WooHong, SungeunGuo, YuanqiangHwang, Bang YeonKim, NahyunMar, WoongchonLee, Dongho
Issue Date
11-5월-2017
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Keywords
Maclura tricuspidata; Cudrania tricuspidata; Snatzke' s method; Circular dichroism; Neuroprotective activity
Citation
TETRAHEDRON, v.73, no.19, pp.2747 - 2759
Indexed
SCIE
SCOPUS
Journal Title
TETRAHEDRON
Volume
73
Number
19
Start Page
2747
End Page
2759
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/83469
DOI
10.1016/j.tet.2017.03.064
ISSN
0040-4020
Abstract
Cudraisoflavone L - T (1-11), cudradihydrochalcone A (12), and cudrabibenzyl A (13), together with 41 known constituents, were isolated from the fruits of Maclura tricuspidata (formerly known as Cudrania tricuspidata). Their structures were determined by spectroscopic and chemical methods including electronic circular dichroism. All isolated compounds were evaluated for their neuroprotective effects against 6-hydroxydopamine (6-OHDA)-induced cell death in human neuroblastoma SH-SY5Y cells, of these six compounds exhibited activities with EC50 values of 4.5-18.6 mu M. Furthermore, the neuroprotective effects against oxygen glucose deprivation (OGD)-induced cell death of all isolated constituents, together with 37 previously reported isoflavones were evaluated. Four compounds showed neuroprotective activities with EC50 values of 3.5-11.9 mu M. (C) 2017 Elsevier Ltd. All rights reserved.
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