KSHV-encoded viral interferon regulatory factor 4 (vIRF4) interacts with IRF7 and inhibits interferon alpha production
DC Field | Value | Language |
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dc.contributor.author | Hwang, Sung-Woo | - |
dc.contributor.author | Kim, Donglk | - |
dc.contributor.author | Jung, Jae U. | - |
dc.contributor.author | Lee, Hye-Ra | - |
dc.date.accessioned | 2021-09-03T06:15:09Z | - |
dc.date.available | 2021-09-03T06:15:09Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-05-06 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/83481 | - |
dc.description.abstract | Before an infection can be completely established, the host immediately turns on the innate immune system through activating the interferon (IFN)-mediated antiviral pathway. Kaposi's sarcoma-associated herpesvirus (KSHV) utilizes a unique antagonistic mechanism of type I IFN-mediated host antiviral immunity by incorporating four viral interferon regulatory factors (vIRF1-4). Herein, we characterized novel immune evasion strategies of vIRF4 to inhibit the IRF7-mediated IFN-alpha production. KSHV vIRF4 specifically interacts with IRF7, resulting in inhibition of IRF7 dimerization and ultimately suppresses IRF7-mediated activation of type I IFN. These results suggest that each of the KSHV vIRFs, including vIRF4, subvert IFN-mediated anti-viral response via different mechanisms. Therefore, it is indicated that KSHV vIRFs are indeed a crucial immunomodulatory component of their life cycles. (C) 2017 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | SARCOMA-ASSOCIATED HERPESVIRUS | - |
dc.subject | ANTIVIRAL RESPONSE | - |
dc.subject | EVASION STRATEGIES | - |
dc.subject | ACTIVATION | - |
dc.subject | INDUCTION | - |
dc.subject | PROTEIN | - |
dc.subject | GENES | - |
dc.subject | HHV-8 | - |
dc.title | KSHV-encoded viral interferon regulatory factor 4 (vIRF4) interacts with IRF7 and inhibits interferon alpha production | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Hye-Ra | - |
dc.identifier.doi | 10.1016/j.bbrc.2017.03.101 | - |
dc.identifier.scopusid | 2-s2.0-85017136137 | - |
dc.identifier.wosid | 000399966700016 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.486, no.3, pp.700 - 705 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 486 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 700 | - |
dc.citation.endPage | 705 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | SARCOMA-ASSOCIATED HERPESVIRUS | - |
dc.subject.keywordPlus | ANTIVIRAL RESPONSE | - |
dc.subject.keywordPlus | EVASION STRATEGIES | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | GENES | - |
dc.subject.keywordPlus | HHV-8 | - |
dc.subject.keywordAuthor | KSHV | - |
dc.subject.keywordAuthor | vIRF4 | - |
dc.subject.keywordAuthor | IRF7 | - |
dc.subject.keywordAuthor | Innate immunity | - |
dc.subject.keywordAuthor | IFN-alpha | - |
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