Verapamil augments carmustine- and irradiation-induced senescence in glioma cells by reducing intracellular reactive oxygen species and calcium ion levels
DC Field | Value | Language |
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dc.contributor.author | Ham, Seok Won | - |
dc.contributor.author | Jeon, Hee-Young | - |
dc.contributor.author | Kim, Hyunggee | - |
dc.date.accessioned | 2021-09-03T06:21:26Z | - |
dc.date.available | 2021-09-03T06:21:26Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-05-01 | - |
dc.identifier.issn | 1010-4283 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/83498 | - |
dc.description.abstract | Resistance to conventional therapies and frequent recurrence are the major obstacles to the treatment of high-grade gliomas, including glioblastoma. Thus, the development of new therapeutic strategies to overcome these obstacles is necessary to improve the treatment outcomes. In this study, we found that verapamil, a pan-adenosine triphosphate-binding cassette transporter and L-type voltage-dependent calcium channel inhibitor, sensitized U87MG glioma cells to carmustine- and irradiation-induced senescence. Furthermore, our results indicated that verapamil treatment, in combination with carmustine and irradiation, rendered U87MG glioma cells and several patient-derived glioma stem cells more sensitive to therapy-induced senescence than individual or dual-combination treatments. When investigating the underlying mechanism, we found that verapamil treatment markedly decreased intracellular reactive oxygen species and calcium ion levels. Reactive oxygen species reduction with N-acetylcysteine, a reactive oxygen species scavenger, rendered U87MG glioma cells more sensitive to carmustine and irradiation whereas the protein kinase C agonist, phorbol 12-myristate 13-acetate, mitigated the effects of carmustine and irradiation. Taken together, our results indicate that verapamil may be a potent therapeutic sensitizer for increasing the effectiveness of glioblastoma treatment. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SAGE PUBLICATIONS LTD | - |
dc.subject | PROTEIN-KINASE-C | - |
dc.subject | MALIGNANT GLIOMAS | - |
dc.subject | ADJUVANT TEMOZOLOMIDE | - |
dc.subject | STEM-CELLS | - |
dc.subject | CANCER | - |
dc.subject | PKC | - |
dc.subject | PROLIFERATION | - |
dc.subject | HETEROGENEITY | - |
dc.subject | GLIOBLASTOMA | - |
dc.subject | RADIOTHERAPY | - |
dc.title | Verapamil augments carmustine- and irradiation-induced senescence in glioma cells by reducing intracellular reactive oxygen species and calcium ion levels | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jeon, Hee-Young | - |
dc.contributor.affiliatedAuthor | Kim, Hyunggee | - |
dc.identifier.doi | 10.1177/1010428317692244 | - |
dc.identifier.scopusid | 2-s2.0-85020005651 | - |
dc.identifier.wosid | 000404625900001 | - |
dc.identifier.bibliographicCitation | TUMOR BIOLOGY, v.39, no.5 | - |
dc.relation.isPartOf | TUMOR BIOLOGY | - |
dc.citation.title | TUMOR BIOLOGY | - |
dc.citation.volume | 39 | - |
dc.citation.number | 5 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | PROTEIN-KINASE-C | - |
dc.subject.keywordPlus | MALIGNANT GLIOMAS | - |
dc.subject.keywordPlus | ADJUVANT TEMOZOLOMIDE | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | PKC | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | HETEROGENEITY | - |
dc.subject.keywordPlus | GLIOBLASTOMA | - |
dc.subject.keywordPlus | RADIOTHERAPY | - |
dc.subject.keywordAuthor | Glioma | - |
dc.subject.keywordAuthor | senescence | - |
dc.subject.keywordAuthor | verapamil | - |
dc.subject.keywordAuthor | carmustine | - |
dc.subject.keywordAuthor | irradiation | - |
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