Dehydroepiandrosterone Sulfate Level Varies Nonlinearly with Symptom Severity in Major Depressive Disorder
DC Field | Value | Language |
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dc.contributor.author | Uh, Dasom | - |
dc.contributor.author | Jeong, Hyun-Ghang | - |
dc.contributor.author | Choi, Kwang-Yeon | - |
dc.contributor.author | Oh, So-Young | - |
dc.contributor.author | Lee, Suji | - |
dc.contributor.author | Kim, Seung-Hyun | - |
dc.contributor.author | Joe, Sook-Haeng | - |
dc.date.accessioned | 2021-09-03T06:24:21Z | - |
dc.date.available | 2021-09-03T06:24:21Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-05 | - |
dc.identifier.issn | 1738-1088 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/83515 | - |
dc.description.abstract | Objective: The pathophysiology of major depressive disorder (MDD) is still not well understood. Conflicting results for surrogate biomarkers in MDD have been reported, which might be a consequence of the heterogeneity of MDD patients. Therefore, we aim to investigate how the severity of depression and various symptom domains are related to the levels of dehydroepiandrosterone sulfate (DHEA-s) in MDD patients. Methods: We recruited 117 subjects from a general practice. Depressive symptoms were assessed using the Beck Depression Inventory (BDI). Depressive symptoms were divided into three subdomains according to BDI items; somatic symptoms, guilt and failure, and mood and inhibition. Results: In subjects with very-mild-to-moderate depression, the DHEA-s level increased as BDI score did. However, the DHEA-s levels in the subjects with severe depression were significantly lower than in subjects with moderate depression (p=0.003). DHEA-s level was correlated with the BDI subscore for guilt and failure in very-mild-to-moderate depression (r=0.365, p=0.006). Conclusion: The DHEA-s level appears to be indicative of MDD severity with respect to depressive symptoms, especially regarding guilt and failure. Our findings suggest that the upregulation of DHEA-s may be a part of a compensatory process in very-mild-to-moderate depression, and the failure of this compensation mechanism may underlie the development of severe depression. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN COLL NEUROPSYCHOPHARMACOLOGY | - |
dc.subject | ACUTE PSYCHOSOCIAL STRESS | - |
dc.subject | ELDERLY-WOMEN | - |
dc.subject | SEX-HORMONES | - |
dc.subject | DHEA | - |
dc.subject | PATHOPHYSIOLOGY | - |
dc.subject | LIFE | - |
dc.subject | PSYCHOPATHOLOGY | - |
dc.subject | EPIDEMIOLOGY | - |
dc.subject | INFLAMMATION | - |
dc.subject | METAANALYSIS | - |
dc.title | Dehydroepiandrosterone Sulfate Level Varies Nonlinearly with Symptom Severity in Major Depressive Disorder | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jeong, Hyun-Ghang | - |
dc.contributor.affiliatedAuthor | Kim, Seung-Hyun | - |
dc.contributor.affiliatedAuthor | Joe, Sook-Haeng | - |
dc.identifier.doi | 10.9758/cpn.2017.15.2.163 | - |
dc.identifier.scopusid | 2-s2.0-85019211631 | - |
dc.identifier.wosid | 000401531000009 | - |
dc.identifier.bibliographicCitation | CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE, v.15, no.2, pp.163 - 169 | - |
dc.relation.isPartOf | CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE | - |
dc.citation.title | CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE | - |
dc.citation.volume | 15 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 163 | - |
dc.citation.endPage | 169 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002225558 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | ACUTE PSYCHOSOCIAL STRESS | - |
dc.subject.keywordPlus | ELDERLY-WOMEN | - |
dc.subject.keywordPlus | SEX-HORMONES | - |
dc.subject.keywordPlus | DHEA | - |
dc.subject.keywordPlus | PATHOPHYSIOLOGY | - |
dc.subject.keywordPlus | LIFE | - |
dc.subject.keywordPlus | PSYCHOPATHOLOGY | - |
dc.subject.keywordPlus | EPIDEMIOLOGY | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordAuthor | Dehydroepiandrosterone sulfate | - |
dc.subject.keywordAuthor | Depression | - |
dc.subject.keywordAuthor | Differential diagnosis | - |
dc.subject.keywordAuthor | Neuroendocrinology | - |
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