Clinical Significance of 5-Fluorouracil Chemosensitivity Testing in Patients with Colorectal Cancer
DC Field | Value | Language |
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dc.contributor.author | Ji, Woong Bae | - |
dc.contributor.author | Um, Jun Won | - |
dc.contributor.author | Ryu, Je Seock | - |
dc.contributor.author | Hong, Kwang Dae | - |
dc.contributor.author | Kim, Jung Sik | - |
dc.contributor.author | Min, Byung Wook | - |
dc.contributor.author | Joung, Sung Yeop | - |
dc.contributor.author | Lee, Ju Han | - |
dc.contributor.author | Kim, Young Sik | - |
dc.date.accessioned | 2021-09-03T06:29:41Z | - |
dc.date.available | 2021-09-03T06:29:41Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-05 | - |
dc.identifier.issn | 0250-7005 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/83521 | - |
dc.description.abstract | Aim: To evaluate whether the results of chemosensitivity testing were associated with prognosis of colorectal cancer patients after adjuvant 5-fluorouracil (FU)/ leucovorin chemotherapy. Patients and Methods: Eighty-nine patients who received 5-FU/leucovorin adjuvant chemotherapy for colorectal cancer were enrolled. Chemosensitivity tests were performed and tumor growth inhibition rate was calculated using the MTT (3-(4,5dimethylthiazol-2-yl)02,5-diphenyl-2H tetrazolium bromide) assay. Results: Fifty-one patients (57.3%) were sensitive to 5-FU according to the chemosensitivity test. After a median follow-up of 64 months, there was a significant difference between the 5-year disease-free survival rates of the chemosensitive and chemo-resistant groups. However, there was no significant difference in the overall 5-year survival between the chemo-sensitive and chemo-resistant groups. Conclusion: A positive 5-FU sensitivity test with in vitro histoculture drug response assay (HDRA) was associated with better disease-free survival. Chemosensitivity may be a prognostic factor for colorectal cancer patients undergoing adjuvant 5-FU/leucovorin chemotherapy. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | INT INST ANTICANCER RESEARCH | - |
dc.subject | DRUG RESPONSE ASSAY | - |
dc.subject | PHASE-II TRIAL | - |
dc.subject | HISTOCULTURE | - |
dc.subject | SURVIVAL | - |
dc.title | Clinical Significance of 5-Fluorouracil Chemosensitivity Testing in Patients with Colorectal Cancer | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ji, Woong Bae | - |
dc.contributor.affiliatedAuthor | Um, Jun Won | - |
dc.contributor.affiliatedAuthor | Hong, Kwang Dae | - |
dc.contributor.affiliatedAuthor | Min, Byung Wook | - |
dc.contributor.affiliatedAuthor | Lee, Ju Han | - |
dc.contributor.affiliatedAuthor | Kim, Young Sik | - |
dc.identifier.doi | 10.21873/anticanres.11616 | - |
dc.identifier.scopusid | 2-s2.0-85019107873 | - |
dc.identifier.wosid | 000402173300066 | - |
dc.identifier.bibliographicCitation | ANTICANCER RESEARCH, v.37, no.5, pp.2679 - 2682 | - |
dc.relation.isPartOf | ANTICANCER RESEARCH | - |
dc.citation.title | ANTICANCER RESEARCH | - |
dc.citation.volume | 37 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 2679 | - |
dc.citation.endPage | 2682 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | DRUG RESPONSE ASSAY | - |
dc.subject.keywordPlus | PHASE-II TRIAL | - |
dc.subject.keywordPlus | HISTOCULTURE | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordAuthor | Colorectal cancer | - |
dc.subject.keywordAuthor | chemotherapy | - |
dc.subject.keywordAuthor | chemosensitivity | - |
dc.subject.keywordAuthor | 5-fluorouracil | - |
dc.subject.keywordAuthor | survival | - |
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