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Molecular Testing of Lymphoproliferative Disorders: Current Status and Perspectives

Authors
Jeon, Yoon KyungYoon, Sun OchPaik, Jin HoKim, Young A.Shin, Bong KyungKim, Hyun-JungCha, Hee JeongKim, Ji EunHuh, JooryungKo, Young-Hyeh
Issue Date
5월-2017
Publisher
KOREAN SOC PATHOLOGISTS
Keywords
Lymphoproliferative disorders; Malignant lymphoma; Pathology; molecular; Molecular diagnostics; Clonality test; Gene translocation; In situ hybridization; fluorescence; Next-generation sequencing
Citation
JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE, v.51, no.3, pp.224 - 241
Indexed
SCOPUS
KCI
Journal Title
JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE
Volume
51
Number
3
Start Page
224
End Page
241
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/83599
DOI
10.4132/jptm.2017.04.09
ISSN
2383-7837
Abstract
Molecular pathologic testing plays an important role for the diagnosis, prognostication and decision of treatment strategy in lymphoproliferative disease. Here, we briefly review the molecular tests currently used for lymphoproliferative disease and those which will be implicated in clinical practice in the near future. Specifically, this guideline addresses the clonality test for B-and T-cell proliferative lesions, molecular cytogenetic tests for malignant lymphoma, determination of cell-of-origin in diffuse large B-cell lymphoma, and molecular genetic alterations incorporated in the 2016 revision of the World Health Organization classification of lymphoid neoplasms. Finally, a new perspective on the next-generation sequencing for diagnostic, prognostic, and therapeutic purpose in malignant lymphoma will be summarized.
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