Clinicopathologic Characteristics and Mutational Status of Succinate Dehydrogenase Genes in Paraganglioma of the Urinary Bladder A Multi-Institutional Korean Study
DC Field | Value | Language |
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dc.contributor.author | Park, Sanghui | - |
dc.contributor.author | Kang, So Young | - |
dc.contributor.author | Kwon, Ghee Young | - |
dc.contributor.author | Kwon, Ji Eun | - |
dc.contributor.author | Kim, Sang Kyum | - |
dc.contributor.author | Kim, Ji Yeon | - |
dc.contributor.author | Kim, Chul Hwan | - |
dc.contributor.author | Kim, Hyun-Jung | - |
dc.contributor.author | Moon, Kyung Chul | - |
dc.contributor.author | Pyo, Ju Yeon | - |
dc.contributor.author | Park, Won Young | - |
dc.contributor.author | Park, Eun Su | - |
dc.contributor.author | Sung, Ji-Youn | - |
dc.contributor.author | Sung, Sun Hee | - |
dc.contributor.author | Oh, Young-Ha | - |
dc.contributor.author | Lee, Seung Eun | - |
dc.contributor.author | Lee, Wonae | - |
dc.contributor.author | Lee, Jong Im | - |
dc.contributor.author | Cho, Nam Hoon | - |
dc.contributor.author | Jung, Soo Jin | - |
dc.contributor.author | Cho, Min-Sun | - |
dc.contributor.author | Cho, Yong Mee | - |
dc.contributor.author | Cho, Hyun Yee | - |
dc.contributor.author | Cha, Eun Jung | - |
dc.contributor.author | Chae, Yang-Seok | - |
dc.contributor.author | Choe, Gheeyoung | - |
dc.contributor.author | Choi, Yeong Jin | - |
dc.contributor.author | Huh, Jooryung | - |
dc.contributor.author | Ro, Jae Y. | - |
dc.date.accessioned | 2021-09-03T06:47:43Z | - |
dc.date.available | 2021-09-03T06:47:43Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-05 | - |
dc.identifier.issn | 0003-9985 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/83625 | - |
dc.description.abstract | Context.-Because of the limited number of available primary bladder paraganglioma (PBPG) cases, the rates of succinate dehydrogenase (SDH) mutations and the clinicopathologic characteristics of SDH-deficient tumors have not been fully studied. Objective.-To define the clinicopathologic and molecular characteristics of PBPGs. Design.-A total of 52 PBPGs were collected retrospectively. SDHA and SDHB immunohistochemical stains were performed. In cases of SDHB expression loss, mutation analyses of SDHB, SDHC, and SDHD were performed. Results.-The clinicopathologic features were analyzed for 52 cases (M:F = 27:25), with a mean age of 56 years (range, 22-79 years). Tumor sizes were 0.5 to 8 cm (mean, 2.4 cm). Tumor necrosis was present in 5 of 52 cases (10%), involvement of muscularis propria in 41 (79%), and lymphovascular tumor invasion in 6 (12%). During a mean follow-up period of 41 months (range, 1-161 months), 3 of 52 patients (6%) developed metastases, but no one died from the disease. Immunohistochemistry for SDHA and SDHB showed that all cases were SDHA intact. Among them, 43 cases had intact SDHB, whereas 9 cases were SDHB deficient. Compared with the SDHB-intact cases, the SDHB-deficient cases were characterized by large tumor sizes (4.5 versus 1.9 cm; P<.001), a higher number of mitoses per 10 high-powered fields (2.6 versus 0.1; P = .002), and frequent lymphovascular tumor invasion (33% versus 7%; P = .02) and metastases (22% versus 2%; P = .02). Mutational analyses for SDHB, SDHC, and SDHD were performed in 9 SDHB-deficient cases. Among them, 6 cases were successfully sequenced and revealed SDHB mutations only. Conclusions.-Large tumor size, a higher number of mitoses, and the presence of lymphovascular tumor invasion and SDHB mutations suggest malignant paraganglioma. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | COLL AMER PATHOLOGISTS | - |
dc.subject | GERMLINE MUTATIONS | - |
dc.subject | SDHB | - |
dc.subject | PHEOCHROMOCYTOMA | - |
dc.subject | NEOPLASMS | - |
dc.subject | BENIGN | - |
dc.title | Clinicopathologic Characteristics and Mutational Status of Succinate Dehydrogenase Genes in Paraganglioma of the Urinary Bladder A Multi-Institutional Korean Study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Chul Hwan | - |
dc.contributor.affiliatedAuthor | Chae, Yang-Seok | - |
dc.identifier.doi | 10.5858/arpa.2016-0403-OA | - |
dc.identifier.scopusid | 2-s2.0-85018360022 | - |
dc.identifier.wosid | 000402173100007 | - |
dc.identifier.bibliographicCitation | ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE, v.141, no.5, pp.671 - 677 | - |
dc.relation.isPartOf | ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE | - |
dc.citation.title | ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE | - |
dc.citation.volume | 141 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 671 | - |
dc.citation.endPage | 677 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Medical Laboratory Technology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Pathology | - |
dc.relation.journalWebOfScienceCategory | Medical Laboratory Technology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Pathology | - |
dc.subject.keywordPlus | GERMLINE MUTATIONS | - |
dc.subject.keywordPlus | SDHB | - |
dc.subject.keywordPlus | PHEOCHROMOCYTOMA | - |
dc.subject.keywordPlus | NEOPLASMS | - |
dc.subject.keywordPlus | BENIGN | - |
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