External validation of the non-alcoholic fatty liver disease fibrosis score for assessing advanced fibrosis in Korean patients
- Authors
- Jun, Dae Won; Kim, Sang Gyune; Park, Sang Hoon; Jin, So-Young; Lee, Ji Sung; Lee, Jin-Woo; Kim, Moon Young; Choi, Dae Hee; Cho, Yong Kyun; Yeon, Jong Eun; Sohn, Joo Hyun
- Issue Date
- 5월-2017
- Publisher
- WILEY
- Keywords
- clinical; metabolism; NAFLD; NASH
- Citation
- JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, v.32, no.5, pp.1094 - 1099
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- Volume
- 32
- Number
- 5
- Start Page
- 1094
- End Page
- 1099
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/83682
- DOI
- 10.1111/jgh.13648
- ISSN
- 0815-9319
- Abstract
- Background: The degree of liver fibrosis in non-alcoholic fatty liver disease (NAFLD) is a critical predictive factor for patient prognosis. This study was intended to perform external validation of the various fibrosis prediction models for assessing advanced fibrosis in Korean NAFLD patients. Methods: A retrospective study of 412 patients with NAFLD confirmed by liver biopsy in hospitals affiliated with the Koran NAFLD study group was conducted and the predictive ability of existing liver fibrosis prediction models including NAFLD fibrosis score (NFS), BARD, and fibrosis-4 were compared. Results: Among 412 samples, 328 liver slides were suitable for evaluation. Advanced fibrosis was present in 60 (18.3%) of the patient samples. Univariate analysis found that the group with advanced fibrosis showed low alanine aminotransferase values and high aspartate aminotransferase/alanine aminotransferase ratios as well as a high incidence of diabetes. However, multivariate analysis showed that only the presence of diabetes and triglycerides was independent risk factors. The receiver operating characteristic was 0.64 in NFS, 0.58 in fibrosis-4, and 0.594 in the BARD model. The NFS was found to be the best at predicting advanced fibrosis among the three prediction models. The negative predictive value which predicts advanced fibrosis using the low cutoff (<-1.455) was high (86.6%). However, the positive predictive value which predicts advanced fibrosis using the high cutoff (>0.676) was 50.0% when we applied the NFS. Conclusion: Negative predictive value using the low cutoff value was high, but positive predictive value using the high cutoff value was low in a Korean NAFLD cohort using NFS.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.