(-)-Epigallocatechin-3-gallate stimulates myogenic differentiation through TAZ activation
DC Field | Value | Language |
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dc.contributor.author | Kim, A. Rum | - |
dc.contributor.author | Kim, Kyung Min | - |
dc.contributor.author | Byun, Mi Ran | - |
dc.contributor.author | Hwang, Jun-Ha | - |
dc.contributor.author | Park, Jung Il | - |
dc.contributor.author | Oh, Ho Taek | - |
dc.contributor.author | Jeong, Mi Gyeong | - |
dc.contributor.author | Hwang, Eun Sook | - |
dc.contributor.author | Hong, Jeong-Ho | - |
dc.date.accessioned | 2021-09-03T07:02:40Z | - |
dc.date.available | 2021-09-03T07:02:40Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-04-29 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/83711 | - |
dc.description.abstract | Muscle loss is a typical process of aging. Green tea consumption is known to slow down the progress of aging. Their underlying mechanisms, however, remain largely unknown. In this study, we investigated the effect of (-)-epigallocatechin-3-gallate (EGCG), a polyphenolic compound of green tea, on myogenic differentiation and found that EGCG significantly increases myogenic differentiation. After EGCG treatment, the expression of myogenic marker genes, such as myosin heavy chain, are increased through activation of TAZ, a transcriptional coactivator with a PDZ-binding motif. TAZ-knockdown does not stimulate EGCG-induced myogenic differentiation. EGCG facilitates the interaction between TAZ and MyoD, which stimulates MyoD-mediated gene transcription. EGCG induces nuclear localization of TAZ through the dephosphorylation of TAZ at its Ser89 residue, which relieves 14-3-3 binding in the cytosol. Interestingly, inactivation of Lats kinase is observed after EGCG treatment, which is responsible for the production of dephosphorylated TAZ. Together, these results suggest that EGCG induces myogenic differentiation through TAZ, suggesting that TAZ plays an important role in EGCG induced muscle regeneration. (C) 2017 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | EPITHELIAL-MESENCHYMAL TRANSITION | - |
dc.subject | SKELETAL-MUSCLE | - |
dc.subject | FIBRO/ADIPOGENIC PROGENITORS | - |
dc.subject | TRANSCRIPTIONAL COACTIVATOR | - |
dc.subject | SATELLITE CELLS | - |
dc.subject | HIPPO PATHWAY | - |
dc.subject | AGED RATS | - |
dc.subject | REGENERATION | - |
dc.subject | RECOVERY | - |
dc.subject | KINASES | - |
dc.title | (-)-Epigallocatechin-3-gallate stimulates myogenic differentiation through TAZ activation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hwang, Jun-Ha | - |
dc.contributor.affiliatedAuthor | Hong, Jeong-Ho | - |
dc.identifier.doi | 10.1016/j.bbrc.2017.03.049 | - |
dc.identifier.scopusid | 2-s2.0-85015319230 | - |
dc.identifier.wosid | 000399261200025 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.486, no.2, pp.378 - 384 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 486 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 378 | - |
dc.citation.endPage | 384 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | EPITHELIAL-MESENCHYMAL TRANSITION | - |
dc.subject.keywordPlus | SKELETAL-MUSCLE | - |
dc.subject.keywordPlus | FIBRO/ADIPOGENIC PROGENITORS | - |
dc.subject.keywordPlus | TRANSCRIPTIONAL COACTIVATOR | - |
dc.subject.keywordPlus | SATELLITE CELLS | - |
dc.subject.keywordPlus | HIPPO PATHWAY | - |
dc.subject.keywordPlus | AGED RATS | - |
dc.subject.keywordPlus | REGENERATION | - |
dc.subject.keywordPlus | RECOVERY | - |
dc.subject.keywordPlus | KINASES | - |
dc.subject.keywordAuthor | Catechins | - |
dc.subject.keywordAuthor | Myogenesis | - |
dc.subject.keywordAuthor | Satellite cells | - |
dc.subject.keywordAuthor | TAZ | - |
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