A cell-autonomous positive-signaling circuit associated with the PDGF-NO-ID4-regulatory axis in glioblastoma cells
DC Field | Value | Language |
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dc.contributor.author | Eun, Kiyoung | - |
dc.contributor.author | Jeon, Hye-Min | - |
dc.contributor.author | Kim, Sung-Ok | - |
dc.contributor.author | Choi, Sang-Hun | - |
dc.contributor.author | Lee, Seon Yong | - |
dc.contributor.author | Jin, Xiong | - |
dc.contributor.author | Kim, Sung-Chan | - |
dc.contributor.author | Kim, Hyunggee | - |
dc.date.accessioned | 2021-09-03T07:03:03Z | - |
dc.date.available | 2021-09-03T07:03:03Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-04-29 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/83713 | - |
dc.description.abstract | Most cancer-related signaling pathways sustain their active or inactive status via genetic mutations or various regulatory mechanisms. Previously, we demonstrated that platelet-derived growth factor (PDGF) activates Notch signaling through nitric oxide (NO)-signaling-driven activation of inhibitor of differentiation 4 (ID4) in glioblastoma (GBM) stem cells (GSCs) and endothelial cells in the vascular niche of GBM, leading to maintenance of GSC traits and GBM progression. Here, we determined that the PDGF-NO-ID4-signaling axis is constantly activated through a positive regulatory circuit. ID4 expression significantly increased PDGF subunit B expression in both in vitro cultures and in vivo tumor xenografts and regulated NO synthase 2 (NOS2) expression and NO production by activating PDGF signaling, as well as that of its receptor (PDGFR). Additionally, ectopic expression of PDGFR alpha, NOS2, or ID4 activated the PDGF-NO-ID4-signaling circuit and enhanced the self-renewal of GBM cell lines. These results suggested that the positive regulatory circuit associated with PDGF-NO-ID4 signaling plays a pivotal role in regulating the self-renewal and tumor-initiating capacity of GSCs and might provide a promising therapeutic target for GBM. (C) 2017 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | NEURAL STEM-CELLS | - |
dc.subject | GROWTH-FACTOR | - |
dc.subject | AUTOCRINE | - |
dc.subject | SURVIVAL | - |
dc.subject | PROGENITORS | - |
dc.subject | SUPPRESSION | - |
dc.subject | ACTIVATION | - |
dc.subject | EXPRESSION | - |
dc.subject | EXPANSION | - |
dc.subject | PATHWAYS | - |
dc.title | A cell-autonomous positive-signaling circuit associated with the PDGF-NO-ID4-regulatory axis in glioblastoma cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Hyunggee | - |
dc.identifier.doi | 10.1016/j.bbrc.2017.03.089 | - |
dc.identifier.scopusid | 2-s2.0-85016020224 | - |
dc.identifier.wosid | 000399261200053 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.486, no.2, pp.564 - 570 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 486 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 564 | - |
dc.citation.endPage | 570 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | NEURAL STEM-CELLS | - |
dc.subject.keywordPlus | GROWTH-FACTOR | - |
dc.subject.keywordPlus | AUTOCRINE | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | PROGENITORS | - |
dc.subject.keywordPlus | SUPPRESSION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | EXPANSION | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordAuthor | Cell-signaling circuit | - |
dc.subject.keywordAuthor | Glioblastoma cells | - |
dc.subject.keywordAuthor | Inhibitor of differentiation 4 | - |
dc.subject.keywordAuthor | Nitric oxide | - |
dc.subject.keywordAuthor | Platelet-derived growth factor | - |
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