Role of piperacillin/tazobactam as a carbapenem-sparing antibiotic for treatment of acute pyelonephritis due to extended-spectrum beta-lactamase-producing Escherichia coli
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yoon, Young Kyung | - |
dc.contributor.author | Kim, Jong Hun | - |
dc.contributor.author | Sohn, JangWook | - |
dc.contributor.author | Yang, Kyung Sook | - |
dc.contributor.author | Kim, Min Ja | - |
dc.date.accessioned | 2021-09-03T07:22:10Z | - |
dc.date.available | 2021-09-03T07:22:10Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-04 | - |
dc.identifier.issn | 0924-8579 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/83799 | - |
dc.description.abstract | Extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-Ec) is a frequent cause of acute pyelonephritis (APN), requiring carbapenem therapy. However, alternatives to carbapenems are needed due to the emergence of carbapenemase-producing micro-organisms. The purpose of this study was to compare the clinical efficacy of piperacillin/tazobactam (TZP) versus ertapenem in the treatment of adult patients with APN caused by ESBL-Ec. A retrospective observational study of APN caused by ESBL-Ec susceptible to TZP was performed at a university-affiliated hospital in the Republic of Korea between February 2011 and June 2013. All adult patients initially treated with in vitro-active TZP were compared with those treated with ertapenem to evaluate antibiotic clinical efficacy. The primary endpoint was treatment failure, defined as a composite of in-hospital mortality, change of initial antibiotic regimen and microbiological eradication failure. During the study period, 68 patients prescribed TZP and 82 patients prescribed ertapenem were eligible for inclusion in the study. There was no significant difference between the two treatment groups in the occurrence of in-hospital mortality, change of initial antibiotic regimen or microbiological eradication failure. In the multivariate analyses, predictors associated with treatment failure included septic shock [odds ratio (OR) = 4.27, 95% confidence interval (CI) 1.66-10.99] and recent administration of immunosuppressive agents (OR = 2.84, 95% CI 1.02-7.91). However, the type of antibiotic was not associated with treatment failure. TZP could be an effective alternative to ertapenem for the treatment of APN caused by ESBL-Ec, sparing carbapenem consumption in the multidrug-resistant era. (C) 2017 Elsevier B.V. and International Society of Chemotherapy. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | URINARY-TRACT-INFECTIONS | - |
dc.subject | GRAM-NEGATIVE BACTERIA | - |
dc.subject | KLEBSIELLA-PNEUMONIAE | - |
dc.subject | ANTIMICROBIAL THERAPY | - |
dc.subject | CLINICAL-OUTCOMES | - |
dc.subject | EMPIRICAL THERAPY | - |
dc.subject | ENTEROBACTERIACEAE | - |
dc.subject | TAZOBACTAM | - |
dc.subject | EPIDEMIOLOGY | - |
dc.subject | KOREA | - |
dc.title | Role of piperacillin/tazobactam as a carbapenem-sparing antibiotic for treatment of acute pyelonephritis due to extended-spectrum beta-lactamase-producing Escherichia coli | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yoon, Young Kyung | - |
dc.contributor.affiliatedAuthor | Sohn, JangWook | - |
dc.contributor.affiliatedAuthor | Kim, Min Ja | - |
dc.identifier.doi | 10.1016/j.ijantimicag.2016.12.017 | - |
dc.identifier.scopusid | 2-s2.0-85014600220 | - |
dc.identifier.wosid | 000402466600003 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, v.49, no.4, pp.410 - 415 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | - |
dc.citation.title | INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | - |
dc.citation.volume | 49 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 410 | - |
dc.citation.endPage | 415 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Infectious Diseases | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Infectious Diseases | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | URINARY-TRACT-INFECTIONS | - |
dc.subject.keywordPlus | GRAM-NEGATIVE BACTERIA | - |
dc.subject.keywordPlus | KLEBSIELLA-PNEUMONIAE | - |
dc.subject.keywordPlus | ANTIMICROBIAL THERAPY | - |
dc.subject.keywordPlus | CLINICAL-OUTCOMES | - |
dc.subject.keywordPlus | EMPIRICAL THERAPY | - |
dc.subject.keywordPlus | ENTEROBACTERIACEAE | - |
dc.subject.keywordPlus | TAZOBACTAM | - |
dc.subject.keywordPlus | EPIDEMIOLOGY | - |
dc.subject.keywordPlus | KOREA | - |
dc.subject.keywordAuthor | Acute pyelonephritis | - |
dc.subject.keywordAuthor | Escherichia coli | - |
dc.subject.keywordAuthor | Extended-spectrum beta-lactamase | - |
dc.subject.keywordAuthor | ESBL | - |
dc.subject.keywordAuthor | Piperacillin/tazobactam | - |
dc.subject.keywordAuthor | Ertapenem | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.