Relations Between Pathological Markers and Radioiodine Scan and 18F-FDG PET/CT Findings in Papillary Thyroid Cancer Patients With Recurrent Cervical Nodal Metastases
- Authors
- 권현우; Kwon, Hyun Woo
- Issue Date
- 6월-2015
- Publisher
- 대한핵의학회
- Keywords
- Thyroid cancer; F-18-fluorodeoxyglucose; Positron emission tomography; Radioiodine
- Citation
- NUCLEAR MEDICINE AND MOLECULAR IMAGING, v.49, no.2, pp.127 - 134
- Indexed
- SCOPUS
KCI
- Journal Title
- NUCLEAR MEDICINE AND MOLECULAR IMAGING
- Volume
- 49
- Number
- 2
- Start Page
- 127
- End Page
- 134
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/83858
- DOI
- 10.1007/s13139-015-0324-6
- ISSN
- 1869-3474
- Abstract
- Purpose The aimof this study was to investigate relationships between the immunohistochemical results and radioiodine scan and 18F-FDG PET findings in papillary thyroid cancer (PTC) patients with recurrent cervical nodal metastases.
Methods A total of 46 PTC patients who had undergone a radioiodine scan and/or 18F-FDG PET/CT and a subsequent operation on recurrent cervical lymph nodes were enrolled.
Twenty-seven patients underwent 18F-FDG PET/CT, 8 underwent radioiodine scans, and 11 underwent both scans.
In all surgical specimens, the immunoexpressions of thyroglobulin (Tg), sodium-iodide symporter (NIS), glucose transporter 1 (Glut-1), and somatostatin receptor 1 and 2A (SSTR1 and SSTR2A) were assessed, and associations between these expressions and radioiodine scan and 18F-FDG PET findings were evaluated.
Results Of the 38 patients who underwent 18F-FDG PET/CT, all patients with weak Tg expression had positive 18F-FDG uptake, while only 45 % of the patients with moderate or strong Tg expression showed positive uptake (p=0.01). The proportion of patients with positive 18F-FDG uptake increased as the degree of Glut-1 expression with luminal accentuation increased. Of the 19 patients who underwent a radioiodine scan, the proportion with positive radioiodine uptake was greater amo
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