Silibinin inhibits TPA-induced cell migration and MMP-9 expression in thyroid and breast cancer cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | JungSeungPil | - |
dc.contributor.author | Jung Seung Pil | - |
dc.date.accessioned | 2021-09-03T07:39:51Z | - |
dc.date.available | 2021-09-03T07:39:51Z | - |
dc.date.created | 2021-06-21 | - |
dc.date.issued | 2013-04 | - |
dc.identifier.issn | 1021-335X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/83915 | - |
dc.description.abstract | Matrix metalloproteinases (MMPs) play an important role in cancer metastasis, cell migration and invasion. Herein, we investigated the effects of silibinin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cell migration and MMP-9 expression in thyroid and breast cancer cells. Our results revealed that the levels of MMP-9 mRNA and protein expression were significantly increased by TPA but not MMP-2 in TPC-1 and MCF7 cells. To verify the regulatory mechanism of TPA-induced MMP-9 expression, we treated TPC-1 and MCF7 cells with the MEK1/2 inhibitor, UO126, and TPA-induced MMP-9 expression was significantly decreased. We also found that TPA-induced cell migration and MMP-9 expression was significantly decreased by silibinin. In addition, TPA-induced phosphorylation of MEK and ERK was also inhibited by silibinin. Taken together, we suggest that silibinin suppresses TPA-induced cell migration and MMP-9 expression through the MEK/ERK-dependent pathway in thyroid and breast cancer cells. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PROFESSOR D A SPANDIDOS | - |
dc.title | Silibinin inhibits TPA-induced cell migration and MMP-9 expression in thyroid and breast cancer cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | JungSeungPil | - |
dc.contributor.affiliatedAuthor | Jung Seung Pil | - |
dc.identifier.doi | 10.3892/or.2013.2252 | - |
dc.identifier.bibliographicCitation | ONCOLOGY REPORTS, v.29, pp.1343 - 1348 | - |
dc.relation.isPartOf | ONCOLOGY REPORTS | - |
dc.citation.title | ONCOLOGY REPORTS | - |
dc.citation.volume | 29 | - |
dc.citation.startPage | 1343 | - |
dc.citation.endPage | 1348 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | silibinin | - |
dc.subject.keywordAuthor | MMP-9 | - |
dc.subject.keywordAuthor | phorbol ester | - |
dc.subject.keywordAuthor | thyroid cancer | - |
dc.subject.keywordAuthor | breast cancer | - |
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