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The value of paradoxical uptake of hepatocellular carcinoma on the hepatobiliary phase of gadoxetic acid-enhanced liver magnetic resonance imaging for the prediction of lipiodol uptake after transcatheter arterial chemoembolization

Authors
Kim, Jeong WooLee, Chang HeePark, Yang ShinSeo, Tae SeokSong, Myung GyuKim, Ji HoonKim, Kyeong AhPark, Cheol Min
Issue Date
4월-2017
Publisher
ELSEVIER IRELAND LTD
Keywords
Hepatocellular carcinoma; Transcatheter arterial chemoembolization; Magnetic resonance imaging; Gadoxetic acid; Lipiodol uptake
Citation
EUROPEAN JOURNAL OF RADIOLOGY, v.89, pp.169 - 176
Indexed
SCIE
SCOPUS
Journal Title
EUROPEAN JOURNAL OF RADIOLOGY
Volume
89
Start Page
169
End Page
176
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/83927
DOI
10.1016/j.ejrad.2017.02.004
ISSN
0720-048X
Abstract
Purpose: To compare the response to transcatheter arterial chemoembolization (TACE) between hepatocellular carcinoma (HCC) with paradoxical uptake on the hepatobiliary phase (HBP) (HCCpara) and HCC with defect on the HBP (HCCdef), and to identify some imaging features that can differentiate between two groups. Materials and methods: Ninety-three HCCs from 54 patients who underwent gadoxetic acid-enhanced liver magnetic resonance imaging (MRI) prior to TACE were included. HCCs were classified into two groups according to the signal intensity (SI) on the HBP: HCCpara and HCCdef. Using post-TACE computed tomography (CT) as a reference standard, initial compact lipiodol uptake was assessed and compared between groups. The arterial enhancement ratio (AER), SI ratios of the arterial phase and HBP, and presence of the capsule appearance were compared between groups. After initial response, local tumor recurrence within 6 and 18 months was evaluated based on follow-up CT or MRI. Results: Fifteen HCCpara and 78 HCCdef were included. Compared to HCCdef, HCCpara showed more frequent initial compact lipiodol uptake (p = 0.009), larger mean size (p = 0.019), lower AER (p = 0.005), higher SI ratio of the HBP (p < 0.0001), and more frequent capsule appearance (p < 0.0001). Local tumor recurrence rate within 6 months was also significantly lower in HCCpara than in HCCdef (p = 0.008). Conclusion: Despite larger size and lower AER, HCCpara showed more frequent initial compact lipiodol uptake and lower early local recurrence rate after TACE than did HCCdef. (C) 2017 Elsevier B. V. All rights reserved.
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