Neuroprotective Effect of Lacosamide on Hypoxic-Ischemic Brain Injury in Neonatal Rats
DC Field | Value | Language |
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dc.contributor.author | Kim, Gun-Ha | - |
dc.contributor.author | Byeon, Jung Hye | - |
dc.contributor.author | Eun, Baik-Lin | - |
dc.date.accessioned | 2021-09-03T07:48:15Z | - |
dc.date.available | 2021-09-03T07:48:15Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-04 | - |
dc.identifier.issn | 1738-6586 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/83961 | - |
dc.description.abstract | Background and Purpose Lacosamide (LCM) is an antiepileptic drug that enhances the slow inactivation of sodium channels and modulates collapsin response mediator protein -2. LCM was recently demonstrated to exert a neuroprotective effect in a murine model of traumatic brain injury and status epilepticus. Assuming the same underlying excitotoxicity-related brain injury mechanism, we hypothesized that LCM would have a neuroprotective effect in hypoxic-ischemic brain injury. Methods We divided rats into three groups at each testing session: pre-or postfed with LCM, fed with normal saline, and sham. A hypoxic-ischemic brain injury was induced by subjecting 7-day-old rats to right carotid artery coagulation followed by 2.5 h of exposure to 8% oxygen. The animals were killed on postnatal day 12 to evaluate the severity of brain damage. Open field testing was also performed between week 2 and week 6, and the Morris water maze test was performed in week 7 after hypoxia-ischemia. Results The incidence of liquefactive cerebral infarction was lower in rats prefed with LCM at 100 mg/kg/dose, with the mortality rate being higher at higher doses (200 and 300 mg/kg/dose). The infarct areas were smaller in LCM-prefed rats in several brain regions including the hemisphere, hippocampus, cortex, and striatum. Spatial learning and memory function were better in LCM-prefed rats (p<0.05). No effect was observed in postfed rats. Conclusions This study suggests that LCM pretreatment exerts a neuroprotective effect on hypoxia-ischemia in neonatal rats. The obtained results suggest that LCM pretreatment could be used as an effective neuroprotective method for neonates under hypoxic-ischemic conditions including heart surgery. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN NEUROLOGICAL ASSOC | - |
dc.subject | ANTIEPILEPTIC DRUGS | - |
dc.subject | CEREBRAL-ISCHEMIA | - |
dc.subject | GLOBAL-ISCHEMIA | - |
dc.subject | GERBIL MODEL | - |
dc.subject | TOPIRAMATE | - |
dc.subject | NEURODEGENERATION | - |
dc.subject | MECHANISMS | - |
dc.subject | CHANNELS | - |
dc.subject | DAMAGE | - |
dc.title | Neuroprotective Effect of Lacosamide on Hypoxic-Ischemic Brain Injury in Neonatal Rats | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Gun-Ha | - |
dc.contributor.affiliatedAuthor | Byeon, Jung Hye | - |
dc.contributor.affiliatedAuthor | Eun, Baik-Lin | - |
dc.identifier.doi | 10.3988/jcn.2017.13.2.138 | - |
dc.identifier.scopusid | 2-s2.0-85017503102 | - |
dc.identifier.wosid | 000398984100003 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL NEUROLOGY, v.13, no.2, pp.138 - 143 | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL NEUROLOGY | - |
dc.citation.title | JOURNAL OF CLINICAL NEUROLOGY | - |
dc.citation.volume | 13 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 138 | - |
dc.citation.endPage | 143 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002211405 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.subject.keywordPlus | ANTIEPILEPTIC DRUGS | - |
dc.subject.keywordPlus | CEREBRAL-ISCHEMIA | - |
dc.subject.keywordPlus | GLOBAL-ISCHEMIA | - |
dc.subject.keywordPlus | GERBIL MODEL | - |
dc.subject.keywordPlus | TOPIRAMATE | - |
dc.subject.keywordPlus | NEURODEGENERATION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | CHANNELS | - |
dc.subject.keywordPlus | DAMAGE | - |
dc.subject.keywordAuthor | brain | - |
dc.subject.keywordAuthor | hypoxia-ischemia | - |
dc.subject.keywordAuthor | lacosamide | - |
dc.subject.keywordAuthor | neuroprotection | - |
dc.subject.keywordAuthor | newborn | - |
dc.subject.keywordAuthor | rat | - |
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