Characteristics of Earlier Versus Delayed Presentation of Very Late Drug-Eluting Stent Thrombosis: An Optical Coherence Tomographic Study
DC Field | Value | Language |
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dc.contributor.author | Lee, Seung-Yul | - |
dc.contributor.author | Ahn, Jung-Min | - |
dc.contributor.author | Mintz, Gary S. | - |
dc.contributor.author | Hur, Seung-Ho | - |
dc.contributor.author | Choi, So-Yeon | - |
dc.contributor.author | Kim, Sang-Wook | - |
dc.contributor.author | Cho, Jin Man | - |
dc.contributor.author | Hong, Soon Jun | - |
dc.contributor.author | Kim, Jin Won | - |
dc.contributor.author | Hong, Young Joon | - |
dc.contributor.author | Lee, Sang-Gon | - |
dc.contributor.author | Shin, Dong-Ho | - |
dc.contributor.author | Kim, Jung-Sun | - |
dc.contributor.author | Kim, Byeong-Keuk | - |
dc.contributor.author | Ko, Young-Guk | - |
dc.contributor.author | Choi, Donghoon | - |
dc.contributor.author | Jang, Yangsoo | - |
dc.contributor.author | Park, Seung-Jung | - |
dc.contributor.author | Hong, Myeong-Ki | - |
dc.date.accessioned | 2021-09-03T07:49:06Z | - |
dc.date.available | 2021-09-03T07:49:06Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-04 | - |
dc.identifier.issn | 2047-9980 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/83966 | - |
dc.description.abstract | Background-The pathophysiology underlying very late drug-eluting stent (DES) thrombosis is not sufficiently understood. Using optical coherence tomography, we investigated characteristics of very late stent thrombosis (VLST) according to different onset times. Methods and Results-A total of 98 patients from 10 South Korean hospitals who underwent optical coherence tomography for evaluation of very late DES thrombosis were retrospectively included in analyses. VLST occurred at a median of 55.1 months after DES implantation. All patients were divided into 2 equal groups of earlier versus delayed presentation of VLST, according to median onset time. In total, 27 patients were treated with next-generation DES and 71 with first-generation DES. Based on optical coherence tomography findings at thrombotic sites, main VLST mechanisms were as follows, in descending order: neoatherosclerosis (34.7%), stent malapposition (33.7%), and uncovered struts without stent malapposition or evagination (24.5%). Compared with patients with earlier VLST, patients with delayed VLST had lower frequency of uncovered struts without stent malapposition or evagination (34.7% versus 14.3%, respectively; P=0.019). Conversely, the frequency of neoatherosclerosis was higher in patients with delayed versus earlier VLST (44.9% versus 24.5%, respectively; P=0.034). The frequency of stent malapposition was not different between patients with earlier and delayed VLST (34.7% versus 32.7%, respectively; P=0.831). The frequency of stent malapposition, evagination, and uncovered struts was still half of delayed VLST. Conclusions-The pathological mechanisms of very late DES thrombosis changed over time. Delayed neointimal healing remained a substantial substrate for VLST, even long after DES implantation. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | INTRAVASCULAR ULTRASOUND | - |
dc.subject | NEOINTIMAL TISSUE | - |
dc.subject | IMPLANTATION | - |
dc.subject | MECHANISMS | - |
dc.subject | NEOATHEROSCLEROSIS | - |
dc.subject | COVERAGE | - |
dc.subject | REGISTRY | - |
dc.title | Characteristics of Earlier Versus Delayed Presentation of Very Late Drug-Eluting Stent Thrombosis: An Optical Coherence Tomographic Study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hong, Soon Jun | - |
dc.contributor.affiliatedAuthor | Kim, Jin Won | - |
dc.identifier.doi | 10.1161/JAHA.116.005386 | - |
dc.identifier.wosid | 000404098500049 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE AMERICAN HEART ASSOCIATION, v.6, no.4 | - |
dc.relation.isPartOf | JOURNAL OF THE AMERICAN HEART ASSOCIATION | - |
dc.citation.title | JOURNAL OF THE AMERICAN HEART ASSOCIATION | - |
dc.citation.volume | 6 | - |
dc.citation.number | 4 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.subject.keywordPlus | INTRAVASCULAR ULTRASOUND | - |
dc.subject.keywordPlus | NEOINTIMAL TISSUE | - |
dc.subject.keywordPlus | IMPLANTATION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | NEOATHEROSCLEROSIS | - |
dc.subject.keywordPlus | COVERAGE | - |
dc.subject.keywordPlus | REGISTRY | - |
dc.subject.keywordAuthor | coronary artery disease | - |
dc.subject.keywordAuthor | drug-eluting stent | - |
dc.subject.keywordAuthor | optical coherence tomography | - |
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