Fbxw7 beta, E3 ubiquitin ligase, negative regulation of primary myoblast differentiation, proliferation and migration
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shin, Kyungshin | - |
dc.contributor.author | Hwang, Sang-Gu | - |
dc.contributor.author | Choi, Ik Joon | - |
dc.contributor.author | Ko, Young-Gyu | - |
dc.contributor.author | Jeong, Jaemin | - |
dc.contributor.author | Kwon, Heechung | - |
dc.date.accessioned | 2021-09-03T07:55:40Z | - |
dc.date.available | 2021-09-03T07:55:40Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-04 | - |
dc.identifier.issn | 1344-3941 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/84002 | - |
dc.description.abstract | Satellite cells attached to skeletal muscle fibers play a crucial role in skeletal muscle regeneration. During regeneration, the satellite cells proliferate, migrate to the damaged region, and fuse to each other. Although it is important to determine the cellular mechanisms controlling myoblast behavior, their regulators are not well understood. In this study, we evaluated the roles of Fbxw7 in primary myoblasts and determined its potential as a therapeutic target for muscle disease. We originally found that Fbxw7 beta, one of the E3 ubiquitin ligase Fbxw7 subtypes, negatively regulates differentiation, proliferation and migration of myoblasts and satellite cells on muscle fiber. However, these phenomena were not observed in myoblasts expressing a dominant-negative, F-box deleted Fbxw7 beta, mutant. Our results suggest that myoblast differentiation potential and muscle regeneration can be regulated by Fbxw7 beta. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | TUMOR-SUPPRESSOR | - |
dc.subject | CYCLIN-E | - |
dc.subject | CELL-DIFFERENTIATION | - |
dc.subject | SKELETAL-MUSCLE | - |
dc.subject | EPITHELIOMESENCHYMAL TRANSFORMATION | - |
dc.subject | MESENCHYMAL TRANSITION | - |
dc.subject | BREAST-CANCER | - |
dc.subject | REGENERATION | - |
dc.subject | EXPRESSION | - |
dc.subject | ADHESION | - |
dc.title | Fbxw7 beta, E3 ubiquitin ligase, negative regulation of primary myoblast differentiation, proliferation and migration | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ko, Young-Gyu | - |
dc.identifier.doi | 10.1111/asj.12687 | - |
dc.identifier.scopusid | 2-s2.0-84984887777 | - |
dc.identifier.wosid | 000398569300018 | - |
dc.identifier.bibliographicCitation | ANIMAL SCIENCE JOURNAL, v.88, no.4, pp.712 - 719 | - |
dc.relation.isPartOf | ANIMAL SCIENCE JOURNAL | - |
dc.citation.title | ANIMAL SCIENCE JOURNAL | - |
dc.citation.volume | 88 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 712 | - |
dc.citation.endPage | 719 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Agriculture | - |
dc.relation.journalWebOfScienceCategory | Agriculture, Dairy & Animal Science | - |
dc.subject.keywordPlus | TUMOR-SUPPRESSOR | - |
dc.subject.keywordPlus | CYCLIN-E | - |
dc.subject.keywordPlus | CELL-DIFFERENTIATION | - |
dc.subject.keywordPlus | SKELETAL-MUSCLE | - |
dc.subject.keywordPlus | EPITHELIOMESENCHYMAL TRANSFORMATION | - |
dc.subject.keywordPlus | MESENCHYMAL TRANSITION | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | REGENERATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | ADHESION | - |
dc.subject.keywordAuthor | differentiation | - |
dc.subject.keywordAuthor | Fbxw7 beta | - |
dc.subject.keywordAuthor | migration | - |
dc.subject.keywordAuthor | myoblast | - |
dc.subject.keywordAuthor | skeletal muscle | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.