Ginsenoside Rc from Panax ginseng exerts anti-inflammatory activity by targeting TANK-binding kinase 1/interferon regulatory factor-3 and p38/ATF-2
DC Field | Value | Language |
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dc.contributor.author | Yu, Tao | - |
dc.contributor.author | Yang, Yanyan | - |
dc.contributor.author | Kwak, Yi-Seong | - |
dc.contributor.author | Song, Gwan Gyu | - |
dc.contributor.author | Kim, Mi-Yeon | - |
dc.contributor.author | Rhee, Man Hee | - |
dc.contributor.author | Cho, Jae Youl | - |
dc.date.accessioned | 2021-09-03T07:58:13Z | - |
dc.date.available | 2021-09-03T07:58:13Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-04 | - |
dc.identifier.issn | 1226-8453 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/84016 | - |
dc.description.abstract | Background: Ginsenoside Rc (G-Rc) is one of the major protopanaxadiol-type saponins isolated from Panax ginseng, a well-known medicinal herb with many beneficial properties including anticancer, anti-inflammatory, antiobesity, and antidiabetic effects. In this study, we investigated the effects of G-Rc on inflammatory responses in vitro and examined the mechanisms of these effects. Methods: The in vitro inflammation system used lipopolysaccharide-treated macrophages, tumor necrosis factor-alpha/interferon-gamma-treated synovial cells, and HEK293 cells transfected with various inducers of inflammation. Results: G-Rc significantly inhibited the expression of macrophage-derived cytokines, such as tumor necrosis factor-alpha and interleukin-1 beta. G-Rc also markedly suppressed the activation of TANK-binding kinase 1/I kappa B kinase epsilon/interferon regulatory factor-3 and p38/ATF-2 signaling in activated RAW264.7 macrophages, human synovial cells, and HEK293 cells. Conclusion: G-Rc exerts its anti-inflammatory actions by suppressing TANK-binding kinase 1/I kappa B kinase epsilon/interferon regulatory factor-3 and p38/ATF-2 signaling. (C) 2017 The Korean Society of Ginseng, Published by Elsevier Korea LLC. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC GINSENG | - |
dc.subject | POTENTIAL THERAPEUTIC TARGET | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | ACTIVATION | - |
dc.subject | TRANSDUCTION | - |
dc.subject | MACROPHAGES | - |
dc.subject | RESPONSES | - |
dc.subject | TBK1 | - |
dc.title | Ginsenoside Rc from Panax ginseng exerts anti-inflammatory activity by targeting TANK-binding kinase 1/interferon regulatory factor-3 and p38/ATF-2 | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Gwan Gyu | - |
dc.identifier.doi | 10.1016/j.jgr.2016.02.001 | - |
dc.identifier.scopusid | 2-s2.0-85015574339 | - |
dc.identifier.wosid | 000400618000003 | - |
dc.identifier.bibliographicCitation | JOURNAL OF GINSENG RESEARCH, v.41, no.2, pp.127 - 133 | - |
dc.relation.isPartOf | JOURNAL OF GINSENG RESEARCH | - |
dc.citation.title | JOURNAL OF GINSENG RESEARCH | - |
dc.citation.volume | 41 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 127 | - |
dc.citation.endPage | 133 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002214986 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.subject.keywordPlus | POTENTIAL THERAPEUTIC TARGET | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | TRANSDUCTION | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | TBK1 | - |
dc.subject.keywordAuthor | anti-inflammatory activity | - |
dc.subject.keywordAuthor | ginsenoside Rc | - |
dc.subject.keywordAuthor | p38 | - |
dc.subject.keywordAuthor | Panax ginseng | - |
dc.subject.keywordAuthor | TANK-binding kinase 1 | - |
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