Current gout treatment and flare in South Korea: Prophylactic duration associated with fewer gout flares
DC Field | Value | Language |
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dc.contributor.author | Choi, Hyo Jin | - |
dc.contributor.author | Lee, Chan Hee | - |
dc.contributor.author | Lee, Joo Hyun | - |
dc.contributor.author | Yoon, Bo Young | - |
dc.contributor.author | Kim, Hyoun Ah | - |
dc.contributor.author | Suh, Chang Hee | - |
dc.contributor.author | Choi, Sang Tae | - |
dc.contributor.author | Song, Jung Soo | - |
dc.contributor.author | Joo, Ho Yeon | - |
dc.contributor.author | Choi, Sung Jae | - |
dc.contributor.author | Lee, Ji Soo | - |
dc.contributor.author | Shin, Kee Chul | - |
dc.contributor.author | Baek, Han Joo | - |
dc.date.accessioned | 2021-09-03T08:03:13Z | - |
dc.date.available | 2021-09-03T08:03:13Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-04 | - |
dc.identifier.issn | 1756-1841 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/84043 | - |
dc.description.abstract | Aim: To evaluate treatment patterns and clinical factors affecting gout flare in South Korea. Methods: We retrospectively examined data from 401 patients seen at nine rheumatology multicenter clinics, under urate lowering therapy (ULT) more than 6 months after stopping prophylactic medication. Demographic data, clinical and laboratory features were collected at the initiation of ULT, upon stopping prophylaxis, and 6 months after. Results: The mean age was 52.2 years and mean disease duration was 25.0 months. The male-to-female count was 387 : 14. The most common ULT starting agent was allopurinol 83.8%. Colchicine (62.3%) was the most commonly prescribed prophylactic agent. During ULT, 134 of the 401 patients (33.4%) experienced at least one gouty attack in the period from stopping prophylaxis to 6 months later. The duration of prophylaxis was different between those with serum uric acid levels below 6 mg/dL and those over 6 mg/dL (P = 0.001). Of the 179 patients (44.6%) who attained target serum uric acid (SUA) levels (6 mg/dL) at the end of prophylaxis, those taking < 6 months of prophylaxis suffered more frequent flares than those taking it >= 6 months (42.9% vs. 26.3%, P = 0.041). The time interval to the first attack after stopping prophylaxis was shorter in the < 6 months group than the >= 6 months group (13.5 weeks vs. 22.5 weeks, P = 0.007). Conclusions: Prophylaxis more than 6 months from initiation of ULT, and achieving target SUA (< 6 mg/dL) at the time of stopping prophylaxis is associated with fewer gout flares during ULT. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | NUTRITION EXAMINATION SURVEY | - |
dc.subject | OF-RHEUMATOLOGY GUIDELINES | - |
dc.subject | GENERAL-PRACTICE | - |
dc.subject | EFFECTIVE MANAGEMENT | - |
dc.subject | NATIONAL-HEALTH | - |
dc.subject | HYPERURICEMIA | - |
dc.subject | THERAPY | - |
dc.subject | POPULATION | - |
dc.subject | PREVALENCE | - |
dc.subject | ARTHRITIS | - |
dc.title | Current gout treatment and flare in South Korea: Prophylactic duration associated with fewer gout flares | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Sung Jae | - |
dc.identifier.doi | 10.1111/1756-185X.12422 | - |
dc.identifier.scopusid | 2-s2.0-85028281849 | - |
dc.identifier.wosid | 000405267300012 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, v.20, no.4, pp.497 - 503 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES | - |
dc.citation.title | INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES | - |
dc.citation.volume | 20 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 497 | - |
dc.citation.endPage | 503 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | NUTRITION EXAMINATION SURVEY | - |
dc.subject.keywordPlus | OF-RHEUMATOLOGY GUIDELINES | - |
dc.subject.keywordPlus | GENERAL-PRACTICE | - |
dc.subject.keywordPlus | EFFECTIVE MANAGEMENT | - |
dc.subject.keywordPlus | NATIONAL-HEALTH | - |
dc.subject.keywordPlus | HYPERURICEMIA | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | POPULATION | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | ARTHRITIS | - |
dc.subject.keywordAuthor | flare | - |
dc.subject.keywordAuthor | gout treatment | - |
dc.subject.keywordAuthor | prophylactic duration | - |
dc.subject.keywordAuthor | serum uric acid | - |
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