Preparation of Chitosan-Coated Nanostructured Lipid Carriers (CH- NLCs) to Control Iron Delivery and Their Potential Application to Food Beverage System
- Authors
- Lee, Sun Ah; Joung, Hee Joung; Park, Hyun Jin; Shin, Gye Hwa
- Issue Date
- 4월-2017
- Publisher
- WILEY
- Keywords
- chitosan; ferric pyrophosphate (FePP); iron fortification; palm oil; nanostructured lipid carriers (NLCs)
- Citation
- JOURNAL OF FOOD SCIENCE, v.82, no.4, pp.904 - 912
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF FOOD SCIENCE
- Volume
- 82
- Number
- 4
- Start Page
- 904
- End Page
- 912
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/84068
- DOI
- 10.1111/1750-3841.13655
- ISSN
- 0022-1147
- Abstract
- Nanostructured lipid carriers (NLCs) and chitosan-coated NLCs (CH-NLCs) were prepared by a combined double emulsion and melt dispersion method. The physicochemical properties of them were investigated to determine the optimum conditions. At 3% emulsifier concentration, the NLCs showed about 191.0 +/- 4.1 nm mean particle size and low polydispersity index value compared to those observed under other conditions. The encapsulation efficiency of CH-NLCs was 83.9% which was about 10% higher than that of NLCs. In vitro release test showed that low release amount of iron from the NLCs (11%) and CH-NLCs (5%) in simulated gastric condition within 3 h, whereas the iron release amounts of the NLCs and CH-NLCs were high (over 77%) in simulated intestinal condition because both NLCs and CH-NLCs were totally destructed in the intestinal condition after 3 h. In the thiobarbituric acid test, the absorbance of milk-fortified NLC and CH-NLCs was lower than that of original milk. Based on these results, CH-NLCs showed great potential for iron fortification in milk.
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