RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. elegans
DC Field | Value | Language |
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dc.contributor.author | Son, Heehwa G. | - |
dc.contributor.author | Seo, Mihwa | - |
dc.contributor.author | Ham, Seokjin | - |
dc.contributor.author | Hwang, Wooseon | - |
dc.contributor.author | Lee, Dongyeop | - |
dc.contributor.author | An, Seon Woo A. | - |
dc.contributor.author | Artan, Murat | - |
dc.contributor.author | Seo, Keunhee | - |
dc.contributor.author | Kaletsky, Rachel | - |
dc.contributor.author | Arey, Rachel N. | - |
dc.contributor.author | Ryu, Youngjae | - |
dc.contributor.author | Ha, Chang Man | - |
dc.contributor.author | Kim, Yoon Ki | - |
dc.contributor.author | Murphy, Coleen T. | - |
dc.contributor.author | Roh, Tae-Young | - |
dc.contributor.author | Nam, Hong Gil | - |
dc.contributor.author | Lee, Seung-Jae V. | - |
dc.date.accessioned | 2021-09-03T08:28:28Z | - |
dc.date.available | 2021-09-03T08:28:28Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-03-09 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/84162 | - |
dc.description.abstract | Long-lived organisms often feature more stringent protein and DNA quality control. However, whether RNA quality control mechanisms, such as nonsense-mediated mRNA decay (NMD), which degrades both abnormal as well as some normal transcripts, have a role in organismal aging remains unexplored. Here we show that NMD mediates longevity in C. elegans strains with mutations in daf-2/insulin/insulin-like growth factor 1 receptor. We find that daf-2 mutants display enhanced NMD activity and reduced levels of potentially aberrant transcripts. NMD components, including smg-2/UPF1, are required to achieve the longevity of several long-lived mutants, including daf-2 mutant worms. NMD in the nervous system of the animals is particularly important for RNA quality control to promote longevity. Furthermore, we find that downregulation of yars-2/tyrosyl-tRNA synthetase, an NMD target transcript, by daf-2 mutations contributes to longevity. We propose that NMD-mediated RNA surveillance is a crucial quality control process that contributes to longevity conferred by daf-2 mutations. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | FRONTOTEMPORAL LOBAR DEGENERATION | - |
dc.subject | EXPRESSION ANALYSIS | - |
dc.subject | DAF-16/FOXO | - |
dc.subject | TDP-43 | - |
dc.subject | NMD | - |
dc.title | RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. elegans | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Yoon Ki | - |
dc.identifier.doi | 10.1038/ncomms14749 | - |
dc.identifier.scopusid | 2-s2.0-85014921415 | - |
dc.identifier.wosid | 000395855900001 | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, v.8 | - |
dc.relation.isPartOf | NATURE COMMUNICATIONS | - |
dc.citation.title | NATURE COMMUNICATIONS | - |
dc.citation.volume | 8 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | FRONTOTEMPORAL LOBAR DEGENERATION | - |
dc.subject.keywordPlus | EXPRESSION ANALYSIS | - |
dc.subject.keywordPlus | DAF-16/FOXO | - |
dc.subject.keywordPlus | TDP-43 | - |
dc.subject.keywordPlus | NMD | - |
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