Correlation of CT imaging features and tumor size with Fuhrman grade of clear cell renal cell carcinoma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Oh, Saelin | - |
dc.contributor.author | Sung, Deuk Jae | - |
dc.contributor.author | Yang, Kyung Sook | - |
dc.contributor.author | Sim, Ki Choon | - |
dc.contributor.author | Han, Na Yeon | - |
dc.contributor.author | Park, Beom Jin | - |
dc.contributor.author | Kim, Min Ju | - |
dc.contributor.author | Cho, Sung Bum | - |
dc.date.accessioned | 2021-09-03T08:46:55Z | - |
dc.date.available | 2021-09-03T08:46:55Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-03 | - |
dc.identifier.issn | 0284-1851 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/84219 | - |
dc.description.abstract | Background: Identification of clinical features to determine the aggressive potential of tumors is highly warranted to stratify patients for adequate treatment. Computed tomography (CT) imaging features of clear cell renal cell carcinoma (ccRCC) may contribute to personalized risk assessment. Purpose: To assess the correlation between CT imaging features and Fuhrman grade of ccRCC, and to identify the predictors of high Fuhrman grade in conjunction with tumor size. Material and Methods: CT scans of 169 patients with 173 pathologically proven ccRCCs were retrospectively reviewed in consensus by two radiologists for the presence of intratumoral necrosis and intratumoral cyst and tumor size. Histologic grade was classified as either low (Fuhrman grade I or II) or high (Fuhrman grade III or IV). Statistical significance was evaluated by using univariate, multivariate regression, receiver operating characteristic (ROC) curve, and Spearman correlation analyses. Results: On CT, 20 of the 173 tumors had intratumoral cysts, 60 had intratumoral necrosis, and 93 showed entirely solid tumors. The odds of high grade were higher with intratumoral necrosis and entirely solid tumor than with intratumoral cyst (P< 0.03). Intratumoral necrosis showed a significantly high odds ratio of 25.73 for high Fuhrman grade. The ROC curve showed a threshold tumor size of 36mm to predict high Fuhrman grade for overall tumors (area under the ROC curve, 0.70). In ccRCCs with intratumoral necrosis or cyst, tumor size did not significantly correlate with Fuhrman grade. Conclusion: Intratumoral necrosis on CT was a strong and independent predictor of biologically aggressive ccRCCs, irrespective of tumor size. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SAGE PUBLICATIONS LTD | - |
dc.subject | MULTIVARIATE-ANALYSIS | - |
dc.subject | PATHOLOGICAL FEATURES | - |
dc.subject | NEPHROMETRY SCORE | - |
dc.subject | PROGNOSTIC VALUE | - |
dc.subject | NUCLEAR GRADE | - |
dc.subject | MASSES | - |
dc.subject | NOMOGRAM | - |
dc.subject | NECROSIS | - |
dc.subject | OUTCOMES | - |
dc.subject | DISEASE | - |
dc.title | Correlation of CT imaging features and tumor size with Fuhrman grade of clear cell renal cell carcinoma | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Sung, Deuk Jae | - |
dc.contributor.affiliatedAuthor | Han, Na Yeon | - |
dc.contributor.affiliatedAuthor | Park, Beom Jin | - |
dc.contributor.affiliatedAuthor | Kim, Min Ju | - |
dc.contributor.affiliatedAuthor | Cho, Sung Bum | - |
dc.identifier.doi | 10.1177/0284185116649795 | - |
dc.identifier.scopusid | 2-s2.0-85011588320 | - |
dc.identifier.wosid | 000394268900018 | - |
dc.identifier.bibliographicCitation | ACTA RADIOLOGICA, v.58, no.3, pp.376 - 384 | - |
dc.relation.isPartOf | ACTA RADIOLOGICA | - |
dc.citation.title | ACTA RADIOLOGICA | - |
dc.citation.volume | 58 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 376 | - |
dc.citation.endPage | 384 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.subject.keywordPlus | MULTIVARIATE-ANALYSIS | - |
dc.subject.keywordPlus | PATHOLOGICAL FEATURES | - |
dc.subject.keywordPlus | NEPHROMETRY SCORE | - |
dc.subject.keywordPlus | PROGNOSTIC VALUE | - |
dc.subject.keywordPlus | NUCLEAR GRADE | - |
dc.subject.keywordPlus | MASSES | - |
dc.subject.keywordPlus | NOMOGRAM | - |
dc.subject.keywordPlus | NECROSIS | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordAuthor | Multidetector computed tomography | - |
dc.subject.keywordAuthor | clear cell renal cell carcinoma | - |
dc.subject.keywordAuthor | Fuhrman grade | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.