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Serum Anti-Mullerian Hormone Levels in Precocious Puberty Girls according to Stage of GnRH Agonist Treatment

Authors
Nam, Hyo-KyoungKim, Hye RyunRhie, Young-JunLee, Kee-Hyoung
Issue Date
3월-2017
Publisher
KOREAN ACAD MEDICAL SCIENCES
Keywords
Puberty; Precocious; Gonadotropin-Releasing Hormone Agonist; Anti-Mullerian Hormone; Ovarian Reserve
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE, v.32, no.3, pp.475 - 479
Indexed
SCIE
SCOPUS
KCI
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
Volume
32
Number
3
Start Page
475
End Page
479
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/84338
DOI
10.3346/jkms.2017.32.3.475
ISSN
1011-8934
Abstract
Few studies have investigated the long-term effects of gonadotropin-releasing hormone (GnRH) agonist treatment on the reproductive function of central precocious puberty (CPP) girls. In this cross-sectional study, we assessed the ovarian function by analyzing the serum anti-Mullerian hormone (AMH) levels of CPP girls. Our study included 505 CPP girls subdivided into 5 groups according to the GnRH agonist treatment stage: group A (before treatment, n = 98), group B (3 months after initiation, n = 103), group C (12 months after initiation, n = 101), group D (24 months after initiation, n = 101), and group E (6 months after discontinuation, n = 102). We compared the serum AMH levels of the CPP girls with those of 100 bone age-matched controls (before treatment: n = 55; after discontinuation: n = 45). At baseline, the mean AMH level of the CPP girls was 5.9 +/- 3.6 ng/mL. The mean AMH level after 3 months of the GnRH agonist treatment was lower (4.7 +/- 3.2 ng/mL, P = 0.047) than that at baseline and recovered after 12 months of treatment. Six months after discontinuation, the AMH levels were similar to those at pre-treatment. Before and after the GnRH agonist treatment, the AMH levels were similar to those of the bone age-matched controls. In the precocious puberty girls, the AMH levels based on the GnRH agonist treatment stage were all within the normal reference range. The results of this study suggest that GnRH agonist treatment has no adverse effects on the reproductive function.
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