CatSperc zeta regulates the structural continuity of sperm Ca2+ signaling domains and is required for normal fertility
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chung, Jean-Ju | - |
dc.contributor.author | Miki, Kiyoshi | - |
dc.contributor.author | Kim, Doory | - |
dc.contributor.author | Shim, Sang-Hee | - |
dc.contributor.author | Shi, Huanan F. | - |
dc.contributor.author | Hwang, Jae Yeon | - |
dc.contributor.author | Cai, Xinjiang | - |
dc.contributor.author | Iseri, Yusuf | - |
dc.contributor.author | Zhuang, Xiaowei | - |
dc.contributor.author | Clapham, David E. | - |
dc.date.accessioned | 2021-09-03T09:21:52Z | - |
dc.date.available | 2021-09-03T09:21:52Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-02-23 | - |
dc.identifier.issn | 2050-084X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/84410 | - |
dc.description.abstract | We report that the Gm7068 (CatSpere) and Tex40 (CatSperz) genes encode novel subunits of a 9-subunit CatSper ion channel complex. Targeted disruption of CatSperz reduces CatSper current and sperm rheotactic efficiency in mice, resulting in severe male subfertility. Normally distributed in linear quadrilateral nanodomains along the flagellum, the complex lacking CatSper zeta is disrupted at similar to 0.8 mu m intervals along the flagellum. This disruption renders the proximal flagellum inflexible and alters the 3D flagellar envelope, thus preventing sperm from reorienting against fluid flow in vitro and efficiently migrating in vivo. Ejaculated CatSperz-null sperm cells retrieved from the mated female uterus partially rescue in vitro fertilization (IVF) that failed with epididymal spermatozoa alone. Human CatSperE is quadrilaterally arranged along the flagella, similar to the CatSper complex in mouse sperm. We speculate that the newly identified CatSper subunit is a late evolutionary adaptation to maximize fertilization inside the mammalian female reproductive tract. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELIFE SCIENCES PUBLICATIONS LTD | - |
dc.subject | CHANNEL COMPLEX | - |
dc.subject | MOUSE SPERMATOZOA | - |
dc.subject | MAMMALIAN SPERM | - |
dc.subject | RAPID EVOLUTION | - |
dc.subject | IN-VITRO | - |
dc.subject | MOTILITY | - |
dc.subject | PROTEINS | - |
dc.subject | CALCIUM | - |
dc.subject | FERTILIZATION | - |
dc.subject | PHOSPHORYLATION | - |
dc.title | CatSperc zeta regulates the structural continuity of sperm Ca2+ signaling domains and is required for normal fertility | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shim, Sang-Hee | - |
dc.identifier.doi | 10.7547/elife.23082.001 | - |
dc.identifier.wosid | 000397642000001 | - |
dc.identifier.bibliographicCitation | ELIFE, v.6 | - |
dc.relation.isPartOf | ELIFE | - |
dc.citation.title | ELIFE | - |
dc.citation.volume | 6 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Life Sciences & Biomedicine - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Biology | - |
dc.subject.keywordPlus | CHANNEL COMPLEX | - |
dc.subject.keywordPlus | MOUSE SPERMATOZOA | - |
dc.subject.keywordPlus | MAMMALIAN SPERM | - |
dc.subject.keywordPlus | RAPID EVOLUTION | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | MOTILITY | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | CALCIUM | - |
dc.subject.keywordPlus | FERTILIZATION | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.