Dual Leucine Zipper Kinase Is Required for Retrograde Injury Signaling and Axonal Regeneration
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yongcheol Cho | - |
dc.contributor.author | Jung Eun Shin | - |
dc.date.accessioned | 2021-09-03T09:50:03Z | - |
dc.date.available | 2021-09-03T09:50:03Z | - |
dc.date.created | 2021-06-21 | - |
dc.date.issued | 2012-06 | - |
dc.identifier.issn | 0896-6273 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/84541 | - |
dc.description.abstract | Here we demonstrate that the dual leucine zipper kinase (DLK) promotes robust regeneration of peripheral axons after nerve injury in mice. Peripheral axon regeneration is accelerated by prior injury; however, DLK KO neurons do not respond to a preconditioning lesion with enhanced regeneration in vivo or in vitro. Assays for activation of transcription factors in injury-induced proregenerative pathways reveal that loss of DLK abolishes upregulation of p-STAT3 and p-cJun in the cell body after axonal injury. DLK is not required for the phosphorylation of STAT3 at the site of nerve injury but is necessary for retrograde transport of p-STAT3 to the cell body. These data demonstrate that DLK enhances regeneration by promoting a retrograde injury signal that is required for the activation of the neuronal proregenerative program. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | CELL PRESS | - |
dc.title | Dual Leucine Zipper Kinase Is Required for Retrograde Injury Signaling and Axonal Regeneration | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yongcheol Cho | - |
dc.contributor.affiliatedAuthor | Jung Eun Shin | - |
dc.identifier.doi | 10.1016/j.neuron.2012.04.028 | - |
dc.identifier.bibliographicCitation | NEURON, v.74, no.6, pp.1015 - 1022 | - |
dc.relation.isPartOf | NEURON | - |
dc.citation.title | NEURON | - |
dc.citation.volume | 74 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1015 | - |
dc.citation.endPage | 1022 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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