Anticancer effects of astaxanthin and α-tocopherol in esophageal cancer cell lines.
DC Field | Value | Language |
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dc.contributor.author | LEE, Sang Woo | - |
dc.contributor.author | Lee BeomJae | - |
dc.contributor.author | PARK JONG JAE | - |
dc.contributor.author | BAK, Young-Tae | - |
dc.contributor.author | Jung, Sung Woo | - |
dc.date.accessioned | 2021-09-03T09:53:43Z | - |
dc.date.available | 2021-09-03T09:53:43Z | - |
dc.date.created | 2021-06-21 | - |
dc.date.issued | 2011-12 | - |
dc.identifier.issn | 1738-3331 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/84572 | - |
dc.description.abstract | Background/Aims: Astaxanthin (AX) has been attributed with potential for protecting the organism against different types of cancer due to its anti-oxidant activity. Also several in vivo and in vitro studies suggest certain naturally occurring vitamin E (i.e. ?-tocopherol) as promising anticancer agents. We assessed the effect of AX and ?-tocopherol (AT) respectively and their combination on human esophageal cancer cell lines to investigate the mechanism of anticancer effect and their therapeutic potential. Materials and Methods: Two human esophageal cancer cell lines (TE-1, TE-4) were exposed to AX (6 to 10?g/mL) and AT (20 to 100?M) for 24 hours. Quantification of proliferation was performed by MTT assay. Cell cycle machinery proteins such as p-AKT, p-p38, cyclin D1, p27 and caspase-3 were investigated by Western blot. Results: Significant inhibition of cell proliferation of AX and AT was observed in TE-4 cell line by a dose-dependent manner. Furthermore, AX and AT as single agents increased the protein expression of p27 and cleaved caspase-3 in TE-4 cell line. The combination of the two agents decreased the expression of cyclin D1, however they did not demonstrate pro-apoptotic effect. Conclusions: AX and AT as single agents are effective at inhibition of cell proliferation and | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | 대한상부위장관헬리코박터학회 | - |
dc.title | Anticancer effects of astaxanthin and α-tocopherol in esophageal cancer cell lines. | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | LEE, Sang Woo | - |
dc.contributor.affiliatedAuthor | Lee BeomJae | - |
dc.contributor.affiliatedAuthor | PARK JONG JAE | - |
dc.contributor.affiliatedAuthor | BAK, Young-Tae | - |
dc.contributor.affiliatedAuthor | Jung, Sung Woo | - |
dc.identifier.bibliographicCitation | KOREAN J HELICOBACTER UP GASTROINTEST RES, v.11, no.3, pp.170 - 175 | - |
dc.relation.isPartOf | KOREAN J HELICOBACTER UP GASTROINTEST RES | - |
dc.citation.title | KOREAN J HELICOBACTER UP GASTROINTEST RES | - |
dc.citation.volume | 11 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 170 | - |
dc.citation.endPage | 175 | - |
dc.type.rims | ART | - |
dc.description.journalClass | 2 | - |
dc.subject.keywordAuthor | Astaxanthin | - |
dc.subject.keywordAuthor | Alpha-tocopherol | - |
dc.subject.keywordAuthor | Esophageal cancer | - |
dc.subject.keywordAuthor | Cell cycle proteins | - |
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