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Anti-diabetic effect of magnesium salt extracts from deep-sea water in C57BLKS/J-db/db mice

Authors
Hwang, Min HeeLee, Dong GunGo, Eun ByeolCho, MijuPark, Young SigChung, Namhyun
Issue Date
2월-2017
Publisher
KOREAN SOC APPLIED BIOLOGICAL CHEMISTRY
Keywords
Anti-diabetic; Deep-sea water; Diabetes mellitus; Magnesium salt extract
Citation
APPLIED BIOLOGICAL CHEMISTRY, v.60, no.1, pp.95 - 99
Indexed
SCIE
SCOPUS
KCI
Journal Title
APPLIED BIOLOGICAL CHEMISTRY
Volume
60
Number
1
Start Page
95
End Page
99
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/84739
DOI
10.1007/s13765-016-0240-1
ISSN
2468-0834
Abstract
Recently, the incidence of diabetes has increased steadily worldwide. Type 2 diabetes constitutes about 90% of all cases of diabetes, and it is associated with many complications. Currently, the drugs for therapy of type 2 diabetes are considerably limited owing to disadvantages such as side effects and high rate of secondary failure. To overcome these problems, it is necessary to develop effective therapeutic agents from safe natural products. Deep-sea water (DSW) is abundant in minerals such as potassium (K), calcium (Ca), and magnesium (Mg). Mg supplements are known for their usefulness in the treatment of type 2 diabetes. In this study, we examined the anti-diabetic effect of Mg salt extracts from DSW in a diabetic mouse model. We observed that the groups treated with Mg salt extract showed better response toward fasting blood glucose level and oral glucose tolerance test when compared to the positive control. Overall, the Mg salt extract improved the symptoms of impaired fasting glucose and glucose tolerance, suggesting that it can be used as an effective agent for the treatment of type 2 diabetes mellitus.
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