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Treadmill exercise alleviates nigrostriatal dopaminergic loss of neurons and fibers in rotenone-induced Parkinson rats

Authors
Shin, Mal-SoonKim, Tae-WoonLee, Jae-MinJi, Eun-SangLim, Baek-Vin
Issue Date
2월-2017
Publisher
KOREAN SOC EXERCISE REHABILITATION
Keywords
Parkinson disease; Rotenone; Treadmill exercise; Substantia nigra; Striatum
Citation
JOURNAL OF EXERCISE REHABILITATION, v.13, no.1, pp.30 - 35
Indexed
SCOPUS
KCI
Journal Title
JOURNAL OF EXERCISE REHABILITATION
Volume
13
Number
1
Start Page
30
End Page
35
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/84768
DOI
10.12965/jer.1734906.453
ISSN
2288-176X
Abstract
Parkinson disease is one of the common brain diseases caused by dopaminergic neuronal loss in the substantia nigra and dopaminergic fiber loss in the striatum. In the present study, the effects of treadmill exercise on motor performance, dopaminergic loss of neurons and fibers, and a-synuclein expression in the nigrostriatum were evaluated using rotenone-induced Parkinson rats. For the induction of Parkinson rats, 3-mg/kg rotenone was injected, once a day for 14 consecutive days. Treadmill running was conducted for 30 min once a day during 14 consecutive days. Rota-rod test for motor balance and coordination and immunohistochemistry for tyrosine hydroxylase and a-synuclein in the nigrostriatum were performed. In the present study, motor balance and coordination was disturbed by induction of rotenone-induced Parkinson disease, in contrast, treadmill exercise alleviated motor dysfunction in the rotenone-induced Parkinson rats. Nigrostriatal dopaminergic loss of neurons and fibers was occurred by induction of rotenone-induced Parkinson disease, in contrast, treadmill exercise alleviated nigrostriatal dopaminergic loss of neurons and fibers in the rotenone-induced Parkinson rats. a-Synuclein expression in the nigrostriatum was enhanced by induction of rotenone-induced Parkinson disease, in contrast, treadmill exercise suppressed alpha-synuclein expression in the rotenone-induced Parkinson rats. Treadmill exercise improved motor function through preservation of nigrostriatal dopaminergic neurons and fibers and suppression of nigrostriatal formation of Lewy bodies in rotenone-induced Parkinson rats.
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