Associations between SLC2A9 polymorphisms and gout susceptibility A meta-analysis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Y. H. | - |
dc.contributor.author | Seo, Y. H. | - |
dc.contributor.author | Kim, J. -H. | - |
dc.contributor.author | Choi, S. J. | - |
dc.contributor.author | Ji, J. D. | - |
dc.contributor.author | Song, G. G. | - |
dc.date.accessioned | 2021-09-03T10:35:57Z | - |
dc.date.available | 2021-09-03T10:35:57Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-02 | - |
dc.identifier.issn | 0340-1855 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/84832 | - |
dc.description.abstract | The aim of this study was to determine whether polymorphisms in solute carrier family 2 and facilitated glucose transporter member 9 (SLC2A9) are associated with susceptibility to gout. A meta-analysis was conducted on associations between the rs12510549, rs16890979, and rs1014290 polymorphisms of SLC2A9 and gout susceptibility using fixed and random effects models. Eleven comparative studies comprising 1,472 patients and 3,269 controls from Caucasian and Asian populations were included in this meta-analysis. The meta-analysis identified a significant negative association between gout and allele 2 (minor) of the rs12510549 polymorphism in the overall population (OR = 0.641, 95 % CI = 0.540-0.761, P = 4.1 x 10(-7)). Stratification by ethnicity identified a significant negative association between this polymorphism and gout in Caucasians (OR = 0.647, 95 % CI = 0.542-0.771, P = 1.2 x 10(-6)) but not in Asians (OR = 0.515, 95 % CI = 0.214-1.236, P = 0.137). The meta-analysis showed a significant negative association between gout and allele 2 of the rs16890979 polymorphism in all study subjects (OR = 0.229, 95 % CI = 0.084-0.628, P = 0.004). Stratification by ethnicity identified a significant negative association between this polymorphism and gout in Caucasians (OR = 0.469, 95 % CI = 0.317-0.695, P = 1.6 x 10(-6)) and in Asians (OR = 0.192, 95 % CI = 0.072-0.513, P = 0.001). A significant negative association was found between allele 2 of the rs1014290 polymorphism and gout susceptibility in Asians (OR = 0.597, 95 % CI = 0.478-0.746, P = 5.4 x 10(-6)) but not in Caucasians (OR = 0.778, 95 % CI = 0.595-1.043, P = 0.095). This meta-analysis shows that the rs12510549, rs16890979, and rs1014290 polymorphisms of SLC2A9 protect against the development of gout in Caucasians and/or Asians. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER HEIDELBERG | - |
dc.subject | URIC-ACID LEVELS | - |
dc.subject | GLUT9 | - |
dc.subject | GENE | - |
dc.subject | ARTHRITIS | - |
dc.subject | EXCRETION | - |
dc.subject | VARIANT | - |
dc.subject | RISK | - |
dc.title | Associations between SLC2A9 polymorphisms and gout susceptibility A meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Y. H. | - |
dc.identifier.doi | 10.1007/s00393-016-0070-x | - |
dc.identifier.scopusid | 2-s2.0-84962637573 | - |
dc.identifier.wosid | 000394465400016 | - |
dc.identifier.bibliographicCitation | ZEITSCHRIFT FUR RHEUMATOLOGIE, v.76, no.1, pp.64 - 70 | - |
dc.relation.isPartOf | ZEITSCHRIFT FUR RHEUMATOLOGIE | - |
dc.citation.title | ZEITSCHRIFT FUR RHEUMATOLOGIE | - |
dc.citation.volume | 76 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 64 | - |
dc.citation.endPage | 70 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | URIC-ACID LEVELS | - |
dc.subject.keywordPlus | GLUT9 | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | ARTHRITIS | - |
dc.subject.keywordPlus | EXCRETION | - |
dc.subject.keywordPlus | VARIANT | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordAuthor | SLC2A9 | - |
dc.subject.keywordAuthor | Polymorphism | - |
dc.subject.keywordAuthor | Gout | - |
dc.subject.keywordAuthor | Meta-analysis | - |
dc.subject.keywordAuthor | Gene | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
145 Anam-ro, Seongbuk-gu, Seoul, 02841, Korea+82-2-3290-2963
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.