Body Mass Index-Related Mortality in Patients with Type 2 Diabetes and Heterogeneity in Obesity Paradox Studies: A Dose-Response Meta-Analysis
DC Field | Value | Language |
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dc.contributor.author | Kwon, Yeongkeun | - |
dc.contributor.author | Kim, Hyun Jung | - |
dc.contributor.author | Park, Sungsoo | - |
dc.contributor.author | Park, Yong-Gyu | - |
dc.contributor.author | Cho, Kyung-Hwan | - |
dc.date.accessioned | 2021-09-03T11:06:17Z | - |
dc.date.available | 2021-09-03T11:06:17Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-01-03 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/84950 | - |
dc.description.abstract | Objective We conducted a systematic review and meta-analysis of studies to quantify the association between body mass index (BMI) and the risks of all-cause and cardiovascular mortality in patients with type 2 diabetes. Methods We included studies assessing the impact of BMI on all-cause and cardiovascular mortality in patients with type 2 diabetes. Data were combined using a random-effects dose-response model. Results Sixteen cohort studies on all-cause mortality (n = 445,125) and two studies on cardiovascular mortality (n = 92,841) were evaluated in the meta-analysis. A non-linear association was observed between BMI and all-cause mortality among patients with type 2 diabetes. With a BMI nadir of 28 - 30 kg/m(2), the risk of all-cause mortality displayed a U-shaped increase. With a BMI nadir of 29 - 31 kg/m(2), the risk of cardiovascular mortality exhibited a gradual non-linear increase for BMI > 31 kg/m(2). Subgroup analyses suggested that study location, diabetes duration, and smoking history may have contributed to heterogeneity among the studies. Conclusions An obesity paradox exists for patients with type 2 diabetes with respect to all-cause and cardiovascular mortality. Study location, diabetes duration, and smoking history might contribute to heterogeneity among obesity paradox studies of patients with type 2 diabetes. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.subject | ALL-CAUSE MORTALITY | - |
dc.subject | CARDIOVASCULAR MORTALITY | - |
dc.subject | REGRESSION-MODELS | - |
dc.subject | TREND ESTIMATION | - |
dc.subject | RISK-FACTORS | - |
dc.subject | WEIGHT-LOSS | - |
dc.subject | DISEASE | - |
dc.subject | ADULTS | - |
dc.subject | ASSOCIATIONS | - |
dc.subject | INDIVIDUALS | - |
dc.title | Body Mass Index-Related Mortality in Patients with Type 2 Diabetes and Heterogeneity in Obesity Paradox Studies: A Dose-Response Meta-Analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Jung | - |
dc.contributor.affiliatedAuthor | Park, Sungsoo | - |
dc.contributor.affiliatedAuthor | Cho, Kyung-Hwan | - |
dc.identifier.doi | 10.1371/journal.pone.0168247 | - |
dc.identifier.scopusid | 2-s2.0-85008489998 | - |
dc.identifier.wosid | 000391612300016 | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.12, no.1 | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 12 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | ALL-CAUSE MORTALITY | - |
dc.subject.keywordPlus | CARDIOVASCULAR MORTALITY | - |
dc.subject.keywordPlus | REGRESSION-MODELS | - |
dc.subject.keywordPlus | TREND ESTIMATION | - |
dc.subject.keywordPlus | RISK-FACTORS | - |
dc.subject.keywordPlus | WEIGHT-LOSS | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | ADULTS | - |
dc.subject.keywordPlus | ASSOCIATIONS | - |
dc.subject.keywordPlus | INDIVIDUALS | - |
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