Effect of ionizing radiation on the DNA damage response in Chlamydomonas reinhardtii
DC Field | Value | Language |
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dc.contributor.author | Koo, Kwang Min | - |
dc.contributor.author | Jung, Sera | - |
dc.contributor.author | Kim, Jin-Baek | - |
dc.contributor.author | Kim, Sang Hoon | - |
dc.contributor.author | Kwon, Soon Jae | - |
dc.contributor.author | Jeong, Won-Joong | - |
dc.contributor.author | Chung, Gook Hyun | - |
dc.contributor.author | Kang, Si-Yong | - |
dc.contributor.author | Choi, Yoon-E | - |
dc.contributor.author | Ahn, Joon-Woo | - |
dc.date.accessioned | 2021-09-03T11:09:13Z | - |
dc.date.available | 2021-09-03T11:09:13Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-01 | - |
dc.identifier.issn | 1976-9571 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/84966 | - |
dc.description.abstract | The DNA damage response (DDR) is induced by various DNA damaging factors and maintains genome stability in all organisms. The Chlamydomonas reinhardtii genome contains putative homologous genes involved in DDR; however, little is known about the functions and responses of these genes to DNA damage. In this study, DDR by gamma radiation was determined in C. reinhardtii. Irradiation with 80, and 200 Gy gamma radiation caused death in approximately 47 and 97 % of C. reinhardtii cells, respectively. The absolute lethality of cells was at 300 Gy. The rate of DNA breaks was also determined using comet assays after exposure to different doses of gamma radiation. Irradiation with 80 and 400 Gy resulted in 17 and 34 % of nuclear degradation in C. reinhardtii cells, respectively. To identify the major DDR pathway of C. reinhardtii induced by gamma radiation, 24 putative DDR genes were selected from the Joint Genome Institute (JGI) database. Gamma radiation significantly affected expression of 15 genes among these. Therefore, these genes displaying expressional changes by gamma radiation are involved in DDR, which indicate that C. reinhardtii may possess a fundamental conserved DDR pathway with higher plants. Furthermore, radiation responsive proteins were identified by proteomic analysis, which are involved in metabolisms of carbohydrate, energy, and photosynthesis. This is the first report to describe the responses of DDR homologous genes to gamma radiation and to identify gamma radiation-responsive proteins in C. reinhardtii. Our data should provide molecular insights into gamma radiation responses including DNA damage in green algae. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | CELL-DEATH | - |
dc.subject | FACTOR-C | - |
dc.subject | REPAIR | - |
dc.subject | ARABIDOPSIS | - |
dc.subject | COMPLEX | - |
dc.subject | GENOME | - |
dc.subject | DEHYDROGENASE | - |
dc.subject | FRAGMENTATION | - |
dc.subject | RECOMBINATION | - |
dc.subject | MAINTENANCE | - |
dc.title | Effect of ionizing radiation on the DNA damage response in Chlamydomonas reinhardtii | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Yoon-E | - |
dc.identifier.doi | 10.1007/s13258-016-0472-9 | - |
dc.identifier.scopusid | 2-s2.0-84991677356 | - |
dc.identifier.wosid | 000392139000006 | - |
dc.identifier.bibliographicCitation | GENES & GENOMICS, v.39, no.1, pp.63 - 75 | - |
dc.relation.isPartOf | GENES & GENOMICS | - |
dc.citation.title | GENES & GENOMICS | - |
dc.citation.volume | 39 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 63 | - |
dc.citation.endPage | 75 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002192553 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.subject.keywordPlus | CELL-DEATH | - |
dc.subject.keywordPlus | FACTOR-C | - |
dc.subject.keywordPlus | REPAIR | - |
dc.subject.keywordPlus | ARABIDOPSIS | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | GENOME | - |
dc.subject.keywordPlus | DEHYDROGENASE | - |
dc.subject.keywordPlus | FRAGMENTATION | - |
dc.subject.keywordPlus | RECOMBINATION | - |
dc.subject.keywordPlus | MAINTENANCE | - |
dc.subject.keywordAuthor | Chlamydomonas reinhardtii | - |
dc.subject.keywordAuthor | DNA damage response (DDR) | - |
dc.subject.keywordAuthor | Gamma radiation | - |
dc.subject.keywordAuthor | DNA repair | - |
dc.subject.keywordAuthor | Proteomic analysis | - |
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