IL-33 inhibits the differentiation and immunosuppressive activity of granulocytic myeloid-derived suppressor cells in tumor-bearing mice
DC Field | Value | Language |
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dc.contributor.author | Lim, Hui Xuan | - |
dc.contributor.author | Choi, Seulah | - |
dc.contributor.author | Cho, Daeho | - |
dc.contributor.author | Kim, Tae Sung | - |
dc.date.accessioned | 2021-09-03T11:28:05Z | - |
dc.date.available | 2021-09-03T11:28:05Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-01 | - |
dc.identifier.issn | 0818-9641 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/85043 | - |
dc.description.abstract | Myeloid-derived suppressor cells (MDSCs) contribute to tumor-mediated immune escape by suppressing antitumor immune responses. Interleukin-33 (IL-33) is capable of regulating various immune cell populations; however, the effects of IL-33 on the differentiation of MDSCs have not been well characterized. In this study, we evaluated the effects of IL-33 on MDSCs and found that IL-33 significantly reduced the differentiation of lineage-negative bone marrow progenitor cells into granulocytic MDSCs (G-MDSCs). IL-33-treated MDSCs exhibited diminished immunosuppressive capacity; reduced inhibition on T-cell proliferation and interferon-gamma production, and diminished production of reactive oxygen species. However, IL-33 treatment did not affect the frequency of monocytic MDSCs (M-MDSCs) or their production of nitric oxide and expression of arginase-1. Additionally, compared with control MDSCs, IL-33-treated MDSCs had reduced capacity to induce the differentiation or expansion of Treg cells. Moreover, in vivo IL-33 administration significantly decreased MDSCs and G-MDSCs accumulation in the spleen and tumor microenvironment. Also, despite increasing CD4(+) and CD8(+) T-cell infiltration, IL-33 administration markedly decreased Treg-cell population in tumor microenvironment. Taken together, our findings indicate that IL-33 reduces the frequency and immunosuppressive activity of G-MDSCs and ultimately the extent of tumor growth. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | REGULATORY T-CELLS | - |
dc.subject | CD8(+) T | - |
dc.subject | DENDRITIC CELLS | - |
dc.subject | INVARIANT NKT | - |
dc.subject | RESPONSES | - |
dc.subject | IMMUNITY | - |
dc.subject | INNATE | - |
dc.subject | GROWTH | - |
dc.subject | EXPRESSION | - |
dc.subject | CYTOKINE | - |
dc.title | IL-33 inhibits the differentiation and immunosuppressive activity of granulocytic myeloid-derived suppressor cells in tumor-bearing mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Tae Sung | - |
dc.identifier.doi | 10.1038/icb.2016.72 | - |
dc.identifier.scopusid | 2-s2.0-84984804677 | - |
dc.identifier.wosid | 000392788300013 | - |
dc.identifier.bibliographicCitation | IMMUNOLOGY AND CELL BIOLOGY, v.95, no.1, pp.99 - 107 | - |
dc.relation.isPartOf | IMMUNOLOGY AND CELL BIOLOGY | - |
dc.citation.title | IMMUNOLOGY AND CELL BIOLOGY | - |
dc.citation.volume | 95 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 99 | - |
dc.citation.endPage | 107 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | REGULATORY T-CELLS | - |
dc.subject.keywordPlus | CD8(+) T | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | INVARIANT NKT | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | IMMUNITY | - |
dc.subject.keywordPlus | INNATE | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CYTOKINE | - |
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