Trichosanthes kirilowil Exerts Androgenic Activity via Regulation of PSA and KLK2 in 22Rv1 Prostate Cancer Cells
DC Field | Value | Language |
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dc.contributor.author | Jeong, Soo-Jin | - |
dc.contributor.author | Chop, Ji-Yoon | - |
dc.contributor.author | Dong, Mi-Sook | - |
dc.contributor.author | Seo, Chang-Seob | - |
dc.contributor.author | Shin, Hyeun-Kyoo | - |
dc.date.accessioned | 2021-09-03T11:31:01Z | - |
dc.date.available | 2021-09-03T11:31:01Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-01 | - |
dc.identifier.issn | 0973-1296 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/85059 | - |
dc.description.abstract | Background: The androgen comprises a group of hormones that play roles in male reproductive activity as well as personal characteristics. Objective: We investigated the androgenic activity of various herbal medicines in human prostate cancer 22Rv1 cells. Materials and Methods: Herbal extracts of Trichosanthes kirilowii (TK), Asarum sieboldii (AS), Sanguisorba officinalis (SO), and Xanthium strumarium (XS) were selected to have androgenic effects based on a preliminary in vitro screening system. Results: TK, AS, SO, and XS enhanced the proliferation of 22Rv1 cells without having cytotoxic effects. All tested herbal extracts increased androgen receptor (AR)-induced transcriptional activity in the absence or presence of dihydrotestosterone (DHT). In an AR-binding assay, TK, but not AS, SO, or XS, produced a significant inhibition of AR binding activity, indicating it has androgenic activity. Additionally, TK treatment positively regulated mRNA expression of the AR-related molecular targets prostate-specific antigen (PSA) and kallikrein 2 (KLK2) compared with untreated control. Conclusion: Taken together, TK-enhanced AR-mediated transcriptional activity might be an attractive candidate drug for treating androgen-related diseases. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MEDKNOW PUBLICATIONS & MEDIA PVT LTD | - |
dc.subject | HUMAN GLANDULAR KALLIKREIN | - |
dc.subject | IN-VITRO | - |
dc.subject | BUTEA-SUPERBA | - |
dc.subject | RECEPTOR | - |
dc.subject | HYPERPLASIA | - |
dc.subject | EXTRACT | - |
dc.subject | RATS | - |
dc.subject | APOPTOSIS | - |
dc.subject | GROWTH | - |
dc.subject | GENE | - |
dc.title | Trichosanthes kirilowil Exerts Androgenic Activity via Regulation of PSA and KLK2 in 22Rv1 Prostate Cancer Cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Dong, Mi-Sook | - |
dc.identifier.doi | 10.4103/0973-1296.197657 | - |
dc.identifier.scopusid | 2-s2.0-85009761345 | - |
dc.identifier.wosid | 000393890600027 | - |
dc.identifier.bibliographicCitation | PHARMACOGNOSY MAGAZINE, v.13, no.49, pp.153 - 158 | - |
dc.relation.isPartOf | PHARMACOGNOSY MAGAZINE | - |
dc.citation.title | PHARMACOGNOSY MAGAZINE | - |
dc.citation.volume | 13 | - |
dc.citation.number | 49 | - |
dc.citation.startPage | 153 | - |
dc.citation.endPage | 158 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.subject.keywordPlus | HUMAN GLANDULAR KALLIKREIN | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | BUTEA-SUPERBA | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | HYPERPLASIA | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordAuthor | Androgen | - |
dc.subject.keywordAuthor | androgen receptor | - |
dc.subject.keywordAuthor | transcription | - |
dc.subject.keywordAuthor | Trichosantheskirilowii | - |
dc.subject.keywordAuthor | 22Rv1 cells | - |
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