Impact of Diltiazem Alone versus Diltiazem with Nitrate on Five-Year Clinical Outcomes in Patients with Significant Coronary Artery Spasm
DC Field | Value | Language |
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dc.contributor.author | Park, Taeshik | - |
dc.contributor.author | Park, Ji Young | - |
dc.contributor.author | Rha, Seung-Woon | - |
dc.contributor.author | Seo, Hong Seog | - |
dc.contributor.author | Choi, Byoung Geol | - |
dc.contributor.author | Choi, Se Yeon | - |
dc.contributor.author | Byun, Jae Kyeong | - |
dc.contributor.author | Park, Sang-Ho | - |
dc.contributor.author | Park, Eun Jin | - |
dc.contributor.author | Choi, Jah Yeon | - |
dc.contributor.author | Park, Sung Hun | - |
dc.contributor.author | Lee, Jae Joong | - |
dc.contributor.author | Lee, Sunki | - |
dc.contributor.author | Na, Jin Oh | - |
dc.contributor.author | Choi, Cheol Ung | - |
dc.contributor.author | Lim, Hong Euy | - |
dc.contributor.author | Kim, Jin Won | - |
dc.contributor.author | Kim, Eung Ju | - |
dc.contributor.author | Park, Chang Gyu | - |
dc.contributor.author | Oh, Dong Joo | - |
dc.date.accessioned | 2021-09-03T11:38:03Z | - |
dc.date.available | 2021-09-03T11:38:03Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-01 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/85097 | - |
dc.description.abstract | Purpose: Calcium channel blockers diltiazem and nitrate have been used as selective coronary vasodilators for patients with significant coronary artery spasm (CAS). However, no study has compared the efficacy of diltiazem alone versus diltiazem with nitrate for long-term clinical outcomes in patients with CAS. Materials and Methods: A total of 2741 consecutive patients without significant coronary artery disease with positive CAS by acetylcholine (Ach) provocation test between November 2004 and May 2014 were enrolled. Significant CAS was defined as a narrowing of >70% by incremental intracoronary injection of 20, 50, and 100 mu g of Ach into the left coronary artery. Patients were assigned to either the diltiazem group (n=842) or the dual group (diltiazem with nitrate, n=1899) at physician discretion. To adjust for potential confounders, a propensity score matching (PSM) analysis was performed using the logistic regression model. After PSM analysis, two well-balanced groups (811 pairs, n=1622, C-statistic=0.708) were generated. Results: At 5 years, there were similar incidences in primary endpoints, including mortality, myocardial infarction, revascularization, and recurrent angina requiring repeat coronary angiography between the two groups. Diltiazem alone was not an independent predictor for major adverse cardiovascular events or recurrent angina requiring repeat coronary angiography. Conclusion: Despite the expected improvement of endothelial function and the relief of CAS, the combination of diltiazem and nitrate treatment was not superior to diltiazem alone in reducing mortality and cardiovascular events up to 5 years in patients with significant CAS. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | YONSEI UNIV COLL MEDICINE | - |
dc.subject | INTRACORONARY ACETYLCHOLINE PROVOCATION | - |
dc.subject | NITRIC-OXIDE | - |
dc.subject | ANGINA | - |
dc.subject | VASOSPASM | - |
dc.subject | JAPANESE | - |
dc.title | Impact of Diltiazem Alone versus Diltiazem with Nitrate on Five-Year Clinical Outcomes in Patients with Significant Coronary Artery Spasm | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Rha, Seung-Woon | - |
dc.contributor.affiliatedAuthor | Seo, Hong Seog | - |
dc.contributor.affiliatedAuthor | Na, Jin Oh | - |
dc.contributor.affiliatedAuthor | Choi, Cheol Ung | - |
dc.contributor.affiliatedAuthor | Lim, Hong Euy | - |
dc.contributor.affiliatedAuthor | Kim, Jin Won | - |
dc.contributor.affiliatedAuthor | Kim, Eung Ju | - |
dc.contributor.affiliatedAuthor | Park, Chang Gyu | - |
dc.identifier.doi | 10.3349/ymj.2017.58.1.90 | - |
dc.identifier.scopusid | 2-s2.0-84995758171 | - |
dc.identifier.wosid | 000396378400012 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, v.58, no.1, pp.90 - 98 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.citation.title | YONSEI MEDICAL JOURNAL | - |
dc.citation.volume | 58 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 90 | - |
dc.citation.endPage | 98 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002177982 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | INTRACORONARY ACETYLCHOLINE PROVOCATION | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | ANGINA | - |
dc.subject.keywordPlus | VASOSPASM | - |
dc.subject.keywordPlus | JAPANESE | - |
dc.subject.keywordAuthor | Diltiazem | - |
dc.subject.keywordAuthor | nitrate | - |
dc.subject.keywordAuthor | coronary vasospasm | - |
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