Is beta-Lactam Plus Macrolide More Effective than beta-Lactam Plus Fluoroquinolone among Patients with Severe Community-Acquired Pneumonia?: a Systemic Review and Meta-Analysis
DC Field | Value | Language |
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dc.contributor.author | Lee, Jong Hoo | - |
dc.contributor.author | Kim, Hyun Jung | - |
dc.contributor.author | Kim, Yee Hyung | - |
dc.date.accessioned | 2021-09-03T11:41:36Z | - |
dc.date.available | 2021-09-03T11:41:36Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-01 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/85114 | - |
dc.description.abstract | Adding either macrolide or fluoroquinolone (FQ) to beta-lactam has been recommended for patients with severe community-acquired pneumonia (CAP). However, due to the limited evidence available, there is a question as to the superiority of the two combination therapies. The MEDLINE, EMBASE, Cochrane Central Register, Scopus, and Web of Science databases were searched for systematic review and meta-analysis. A total of eight trials were analyzed. The total number of patients in the beta-lactam plus macrolide (BL-M) and beta-lactam plus fluoroquinolone (BL-F) groups was 2,273 and 1,600, respectively. Overall mortality of the BL-M group was lower than that of the BL-F group (19.4% vs. 26.8%), which showed statistical significance (odds ratio [OR], 0.68; 95% confidence interval [CI], 0.49 to 0.94; P = 0.02). Length of hospital stay was reduced in the BL-M group compared to the BL-F group (mean difference, -3.05 days; 95% CI, -6.01 to -0.09; P = 0.04). However, there was no significant difference in length of intensive care unit (ICU) stay between the two groups. Among patients with severe CAP, BL-M therapy may better reduce overall mortality and length of hospital stay than BL-F therapy. However, we could not elicit strong conclusions from the available trials due to high risk of bias and methodological limitations. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | - |
dc.subject | CRITICALLY-ILL PATIENTS | - |
dc.subject | SEVERE SEPSIS | - |
dc.subject | ANTIBIOTICS | - |
dc.subject | OUTCOMES | - |
dc.subject | MONOTHERAPY | - |
dc.subject | GUIDELINES | - |
dc.subject | MORTALITY | - |
dc.subject | SURVIVAL | - |
dc.subject | KOREA | - |
dc.title | Is beta-Lactam Plus Macrolide More Effective than beta-Lactam Plus Fluoroquinolone among Patients with Severe Community-Acquired Pneumonia?: a Systemic Review and Meta-Analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Jung | - |
dc.identifier.doi | 10.3346/jkms.2017.32.1.77 | - |
dc.identifier.scopusid | 2-s2.0-85008193428 | - |
dc.identifier.wosid | 000392202300012 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, v.32, no.1, pp.77 - 84 | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.title | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.volume | 32 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 77 | - |
dc.citation.endPage | 84 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.identifier.kciid | ART002185673 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | CRITICALLY-ILL PATIENTS | - |
dc.subject.keywordPlus | SEVERE SEPSIS | - |
dc.subject.keywordPlus | ANTIBIOTICS | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordPlus | MONOTHERAPY | - |
dc.subject.keywordPlus | GUIDELINES | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | KOREA | - |
dc.subject.keywordAuthor | Pneumonia | - |
dc.subject.keywordAuthor | Intensive Care Units | - |
dc.subject.keywordAuthor | Mortality | - |
dc.subject.keywordAuthor | Macrolides | - |
dc.subject.keywordAuthor | Fluoroquinolone | - |
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