Clinical Outcomes of Posterior Versus Anterior Circulation Infarction With Low National Institutes of Health Stroke Scale Scores
- Authors
- Kim, Joon-Tae; Park, Man-Seok; Choi, Kang-Ho; Kim, Beom Joon; Han, Moon-Ku; Park, Tai Hwan; Park, Sang-Soon; Lee, Kyung Bok; Lee, Byung-Chul; Yu, Kyung-Ho; Oh, Mi Sun; Cha, Jae Kwan; Kim, Dae-Hyun; Nah, Hyun-Wook; Lee, Jun; Lee, Soo Joo; Ko, Youngchai; Kim, Jae Guk; Park, Jong-Moo; Kang, Kyusik; Cho, Yong-Jin; Hong, Keun-Sik; Choi, Jay Chol; Kim, Dong-Eog; Ryu, Wi-Sun; Shin, Dong-Ick; Yeo, Min-Ju; Kim, Wook-Joo; Lee, Juneyoung; Lee, Ji Sung; Bae, Hee-Joon; Saver, Jeffrey L.; Cho, Ki-Hyun
- Issue Date
- 1월-2017
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Keywords
- basilar artery; cerebral infarction; ischemic attack, transient; risk; stroke
- Citation
- STROKE, v.48, no.1, pp.55 - +
- Indexed
- SCIE
SCOPUS
- Journal Title
- STROKE
- Volume
- 48
- Number
- 1
- Start Page
- 55
- End Page
- +
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/85129
- DOI
- 10.1161/STROKEAHA.116.013432
- ISSN
- 0039-2499
- Abstract
- Background and Purpose-We compared baseline characteristics and outcomes at 3 months between patients with minor anterior circulation infarction (ACI) versus minor posterior circulation infarction (PCI), including the influence of large vessel disease on outcomes. Methods-This study is an analysis of a prospective multicenter registry database in South Korea. Eligibility criteria were patients with ischemic stroke admitted within 7 days of stroke onset, lesions in either anterior or posterior circulation, and National Institutes of Health Stroke Scale score of <= 4 at baseline. Patients were divided into 4 groups for further analysis: minor ACI with and without internal carotid artery/middle cerebral artery large vessel disease and minor PCI with and without vertebrobasilar large vessel disease. Results-A total of 7178 patients (65.2 +/- 12.6 years) were analyzed in this study, and 2233 patients (31.1%) had disability (modified Rankin Scale score 2-6) at 3 months. Disability was 32.3% in minor PCI and 30.3% in minor ACI (P=0.07), and death was 1.3% and 1.5%, respectively (P=0.82). In a multivariable logistic regression analysis, minor PCI was significantly associated with disability at 3 months when compared with minor ACI (odds ratio, 1.23; 95% confidence interval, 1.09-1.37; P<0.001). In pairwise comparisons, minor PCI with vertebrobasilar large vessel disease was independently associated with disability at 3 months, compared with the other 3 groups. Conclusions-Our study showed that minor PCI exhibited more frequent disability at 3 months than minor ACI. Especially, the presence of vertebrobasilar large vessel disease in minor PCI had a substantially higher risk of disability. Our results suggest that minor PCI with vertebrobasilar large vessel disease could require more meticulous care and are important targets for further study.
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