Epigenetic Regulation of Axon Regeneration after Neural Injury
- Authors
- Shin, Jung Eun; Cho, Yongcheol
- Issue Date
- 1월-2017
- Publisher
- KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
- Keywords
- axon regeneration; epigenetic regulation; histone modification; nerve injury
- Citation
- MOLECULES AND CELLS, v.40, no.1, pp.10 - 16
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- MOLECULES AND CELLS
- Volume
- 40
- Number
- 1
- Start Page
- 10
- End Page
- 16
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/85137
- DOI
- 10.14348/molcells.2017.2311
- ISSN
- 1016-8478
- Abstract
- When peripheral axons are damaged, neuronal injury signaling pathways induce transcriptional changes that support axon regeneration and consequent functional recovery. The recent development of bioinformatics techniques has allowed for the identification of many of the regeneration-associated genes that are regulated by neural injury, yet it remains unclear how global changes in transcriptome are coordinated. In this article, we review recent studies on the epigenetic mechanisms orchestrating changes in gene expression in response to nerve injury. We highlight the importance of epigenetic mechanisms in discriminating efficient axon regeneration in the peripheral nervous system and very limited axon regrowth in the central nervous system and discuss the therapeutic potential of targeting epigenetic regulators to improve neural recovery.
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Collections - Graduate School > Department of Life Sciences > 1. Journal Articles
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