Transplantation of Adipose-Derived Stem Cell Sheet Attenuates Adverse Cardiac Remodeling in Acute Myocardial Infarction
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jong-Ho | - |
dc.contributor.author | Joo, Hyung Joon | - |
dc.contributor.author | Kim, Mina | - |
dc.contributor.author | Choi, Seung-Cheol | - |
dc.contributor.author | Lee, Jeong Ik | - |
dc.contributor.author | Hong, Soon Jun | - |
dc.contributor.author | Lim, Do-Sun | - |
dc.date.accessioned | 2021-09-03T11:46:42Z | - |
dc.date.available | 2021-09-03T11:46:42Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-01 | - |
dc.identifier.issn | 1937-3341 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/85139 | - |
dc.description.abstract | Adipose-derived stem cell (ADSC) transplantation has been proposed to improve cardiac function and acute myocardial infarction (AMI). Recently, cell sheet technology has been investigated for its potential applicability in cardiac injury. However, a detailed comparison of the functional recovery in the injured myocardium between cell sheets and conventional cell injection has not been adequately examined. ADSCs were isolated from the inguinal fat tissue of ICR mice. Three groups of AMI induction only (sham), intramyocardial injection of ADSCs (imADSC), and ADSC sheet transplantation (shADSC) were compared by using rat AMI models. Engraftment of ADSCs was better sustained through 28 days in the shADSC group compared with the imADSC group. Ejection fraction was improved in both imADSC and shADSC groups compared with the sham group. Ventricular wall thickness in the infarct zone was higher in the shADSC group compared with both imADSC and sham groups. Growth factor and cytokine expression in the implanted heart tissue were higher in the shADSC group compared with both imADSC and sham groups. Furthermore, only the shADSC group showed donor-derived vessels at the peri-infarct zone. Taken together, these results indicate that, although shADSC resulted in a similar improvement in left ventricular systolic function, it significantly promoted cellular engraftment and upregulated growth factor and cytokine expression, and, ultimately, attenuated adverse cardiac remodeling in rat AMI models compared with imADSC. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MARY ANN LIEBERT, INC | - |
dc.subject | LEFT-VENTRICULAR FUNCTION | - |
dc.subject | BONE-MARROW | - |
dc.subject | 3-DIMENSIONAL TISSUES | - |
dc.subject | INTRACORONARY | - |
dc.subject | DELIVERY | - |
dc.subject | REPAIR | - |
dc.subject | EXPRESSION | - |
dc.subject | CYTOKINE | - |
dc.subject | NEOVASCULARIZATION | - |
dc.subject | REGENERATION | - |
dc.title | Transplantation of Adipose-Derived Stem Cell Sheet Attenuates Adverse Cardiac Remodeling in Acute Myocardial Infarction | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jong-Ho | - |
dc.contributor.affiliatedAuthor | Joo, Hyung Joon | - |
dc.contributor.affiliatedAuthor | Choi, Seung-Cheol | - |
dc.contributor.affiliatedAuthor | Hong, Soon Jun | - |
dc.contributor.affiliatedAuthor | Lim, Do-Sun | - |
dc.identifier.doi | 10.1089/ten.tea.2016.0023 | - |
dc.identifier.scopusid | 2-s2.0-85027975820 | - |
dc.identifier.wosid | 000391740200001 | - |
dc.identifier.bibliographicCitation | TISSUE ENGINEERING PART A, v.23, no.1-2, pp.1 - 11 | - |
dc.relation.isPartOf | TISSUE ENGINEERING PART A | - |
dc.citation.title | TISSUE ENGINEERING PART A | - |
dc.citation.volume | 23 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 11 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Cell & Tissue Engineering | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | LEFT-VENTRICULAR FUNCTION | - |
dc.subject.keywordPlus | BONE-MARROW | - |
dc.subject.keywordPlus | 3-DIMENSIONAL TISSUES | - |
dc.subject.keywordPlus | INTRACORONARY | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | REPAIR | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CYTOKINE | - |
dc.subject.keywordPlus | NEOVASCULARIZATION | - |
dc.subject.keywordPlus | REGENERATION | - |
dc.subject.keywordAuthor | acute myocardial infarction | - |
dc.subject.keywordAuthor | adipose-derived stem cell | - |
dc.subject.keywordAuthor | ADSC sheet | - |
dc.subject.keywordAuthor | cardiac remodeling | - |
dc.subject.keywordAuthor | engraftment | - |
dc.subject.keywordAuthor | intramyocardial injection | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.