Secreted tryptophanyl-tRNA synthetase as a primary defence system against infection
DC Field | Value | Language |
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dc.contributor.author | Ahn, Young Ha | - |
dc.contributor.author | Park, Sunyoung | - |
dc.contributor.author | Choi, Jeong June | - |
dc.contributor.author | Park, Bo-Kyung | - |
dc.contributor.author | Rhee, Kyung Hee | - |
dc.contributor.author | Kang, Eunjoo | - |
dc.contributor.author | Ahn, Soyeon | - |
dc.contributor.author | Lee, Chul-Ho | - |
dc.contributor.author | Lee, Jong Soo | - |
dc.contributor.author | Inn, Kyung-Soo | - |
dc.contributor.author | Cho, Mi-La | - |
dc.contributor.author | Park, Sung-Hwan | - |
dc.contributor.author | Park, Kyunghee | - |
dc.contributor.author | Park, Hye Jung | - |
dc.contributor.author | Lee, Jae-Hyun | - |
dc.contributor.author | Park, Jung-Won | - |
dc.contributor.author | Kwon, Nam Hoon | - |
dc.contributor.author | Shim, Hyunbo | - |
dc.contributor.author | Han, Byung Woo | - |
dc.contributor.author | Kim, Pilhan | - |
dc.contributor.author | Lee, Joo-Youn | - |
dc.contributor.author | Jeon, Youngho | - |
dc.contributor.author | Huh, Jin Won | - |
dc.contributor.author | Jin, Mirim | - |
dc.contributor.author | Kim, Sunghoon | - |
dc.date.accessioned | 2021-09-03T11:47:38Z | - |
dc.date.available | 2021-09-03T11:47:38Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2017-01 | - |
dc.identifier.issn | 2058-5276 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/85144 | - |
dc.description.abstract | The N-terminal truncated form of a protein synthesis enzyme, tryptophanyl-tRNA synthetase (mini-WRS), is secreted as an angiostatic ligand. However, the secretion and function of the full-length WRS (FL-WRS) remain unknown. Here, we report that the FL-WRS, but not mini-WRS, is rapidly secreted upon pathogen infection to prime innate immunity. Blood levels of FL-WRS were increased in sepsis patients, but not in those with sterile inflammation. FL-WRS was secreted from monocytes and directly bound to macrophages via a toll-like receptor 4 (TLR4)-myeloid differentiation factor 2 (MD2) complex to induce phagocytosis and chemokine production. Administration of FL-WRS into Salmonella typhimurium-infected mice reduced the levels of bacteria and improved mouse survival, whereas its titration with the specific antibody aggravated the infection. The N-terminal 154-amino-acid eukaryote-specific peptide of WRS was sufficient to recapitulate FL-WRS activity and its interaction mode with TLR4-MD2 is now suggested. Based on these results, secretion of FL-WRS appears to work as a primary defence system against infection, acting before full activation of innate immunity. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | CLASSIFICATION CRITERIA | - |
dc.subject | SIGNALING PATHWAYS | - |
dc.subject | SJOGRENS-SYNDROME | - |
dc.subject | AMERICAN-COLLEGE | - |
dc.subject | CUTTING EDGE | - |
dc.subject | TLR4 | - |
dc.subject | MICE | - |
dc.subject | LIPOPOLYSACCHARIDE | - |
dc.subject | RECOGNITION | - |
dc.subject | COMPONENTS | - |
dc.title | Secreted tryptophanyl-tRNA synthetase as a primary defence system against infection | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jeon, Youngho | - |
dc.identifier.doi | 10.1038/nmicrobiol.2016.191 | - |
dc.identifier.scopusid | 2-s2.0-84992362225 | - |
dc.identifier.wosid | 000396366300011 | - |
dc.identifier.bibliographicCitation | NATURE MICROBIOLOGY, v.2, no.1 | - |
dc.relation.isPartOf | NATURE MICROBIOLOGY | - |
dc.citation.title | NATURE MICROBIOLOGY | - |
dc.citation.volume | 2 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.subject.keywordPlus | CLASSIFICATION CRITERIA | - |
dc.subject.keywordPlus | SIGNALING PATHWAYS | - |
dc.subject.keywordPlus | SJOGRENS-SYNDROME | - |
dc.subject.keywordPlus | AMERICAN-COLLEGE | - |
dc.subject.keywordPlus | CUTTING EDGE | - |
dc.subject.keywordPlus | TLR4 | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | LIPOPOLYSACCHARIDE | - |
dc.subject.keywordPlus | RECOGNITION | - |
dc.subject.keywordPlus | COMPONENTS | - |
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