만성 폐쇄성 폐질환에서 백색질다발통합성 변화: TRActs Constrained by UnderLying Anatomy를 이용한 신경다발 분석Alterations of White Matter Integrity in Patients with Chronic Obstructive Pulmonary Disease: Tract-Based Analysis Using TRActs Constrained by UnderLying Anatomy
- Other Titles
- Alterations of White Matter Integrity in Patients with Chronic Obstructive Pulmonary Disease: Tract-Based Analysis Using TRActs Constrained by UnderLying Anatomy
- Authors
- 엄미경; 이승환; 김우진; 조성휘; 윤혜경; 임명남; 편성범; 태우석; 김삼수
- Issue Date
- 2017
- Publisher
- 대한영상의학회
- Keywords
- Diffusion Tensor Imaging White Matter Chronic Obstructive Pulmonary Disease
- Citation
- 대한영상의학회지, v.77, no.3, pp.148 - 156
- Indexed
- KCI
- Journal Title
- 대한영상의학회지
- Volume
- 77
- Number
- 3
- Start Page
- 148
- End Page
- 156
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/85357
- DOI
- 10.3348/jksr.2017.77.3.148
- ISSN
- 1738-2637
- Abstract
- Purpose: To investigate structural brain changes and their relationship with cognitive function by determining the alterations of white matter integrity and changes in hippocampal volume that occur during chronic obstructive pulmonary disease (COPD).
Materials and Methods: Diffusion tensor images and 3D-T1 MR images were acquired in 13 male nonhypoxemic COPD patients and 13 age- and gender-matched healthy controls. Global probabilistic tractography was used to assess a total of 18 major tracts. We examined the association between the hippocampal volume and diffusivity parameters of white matter tracts.
Results: A significant difference in diffusion parameters between groups was identified for 11 white matter bundles (p < 0.05). No association was demonstrated between the normalized hippocampus volume and diffusion parameters among the participants. Significant associations between Korean version of the Mini-Mental State Examination (KMMSE) scores and diffusivities were found for six tracts (p < 0.05). Of note, the mean diffusivity (MD) and redial diffusivity (RD) of the left superior longitudinal fasciculus parietal segment showed a significant negative correlation with the K-MMSE score (MD: r = -0.623, p = 0.001; RD: r = -0.408, p = 0.048).
Conclusion: Altered white matter integrity was demonstrated across regional white matter bundles, including the superior longitudinal fasciculus, in COPD patients, and it was related to cognitive function. Changes in the volume of the hippocampus should be investigated in further studies.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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