The outcomes of intensified 5-fluorouracil plus leucovorin chemotherapy for preoperative chemoradiation in rectal cancers
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 하늘 | - |
dc.contributor.author | 홍광대 | - |
dc.contributor.author | 지웅배 | - |
dc.contributor.author | 김정식 | - |
dc.contributor.author | 엄준원 | - |
dc.date.accessioned | 2021-09-03T13:50:00Z | - |
dc.date.available | 2021-09-03T13:50:00Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1738-8082 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/85968 | - |
dc.description.abstract | Purpose: The clinical benefit of intensified neoadjuvant chemoradiotherapy (CRT) in rectal cancer has not been proved. We investigated clinical outcomes of intensified 5-fluorouracil plus leucovorin (5-FU/LV) chemotherapy. Methods: We retrospectively analyzed 45 patients with locally advanced rectal adenocarcinoma who underwent neoadjuvant CRT between 2010 and 2015. Intensified group took additional 1 cycle of 5-FU/LV chemotherapy after radiation completion (resting period) before surgery, compared to conventional group. Results: Eighteen patients were in conventional group and 27 were in intensified group. Median follow-up duration was 33.7 months (range, 7.8–75.6 months). Complete response rate was 11.4% (5/45). Twelve patients in conventional group and 16 patients in intensified group achieved downstaging (P=0.435). In aspect of toxicity, anemia and thrombocytopenia tended to be more frequent in intensified group without statistical difference. There was also no difference in survival between two groups. Conclusion: The intensified CRT with additional 1 cycle of 5-FU/LV in rectal cancer revealed no clinical benefit compared to conventional regimen. Considering that the adverse event was minimal and generally acceptable, further research with additional cycles of 5-FU/LV is needed to prove a real benefit of intensified CRT. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | 대한종양외과학회 | - |
dc.title | The outcomes of intensified 5-fluorouracil plus leucovorin chemotherapy for preoperative chemoradiation in rectal cancers | - |
dc.title.alternative | The outcomes of intensified 5-fluorouracil plus leucovorin chemotherapy for preoperative chemoradiation in rectal cancers | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 지웅배 | - |
dc.identifier.bibliographicCitation | 대한종양외과학회지, v.13, no.2, pp.147 - 151 | - |
dc.relation.isPartOf | 대한종양외과학회지 | - |
dc.citation.title | 대한종양외과학회지 | - |
dc.citation.volume | 13 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 147 | - |
dc.citation.endPage | 151 | - |
dc.type.rims | ART | - |
dc.identifier.kciid | ART002307538 | - |
dc.description.journalClass | 2 | - |
dc.description.journalRegisteredClass | kci | - |
dc.description.journalRegisteredClass | other | - |
dc.subject.keywordAuthor | 5-fluorouracil | - |
dc.subject.keywordAuthor | Rectal neoplasms | - |
dc.subject.keywordAuthor | Consolidation chemotherapy | - |
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